H
Helen Chim
Researcher at Harvard University
Publications - 7
Citations - 1492
Helen Chim is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin receptor & Sirtuin 1. The author has an hindex of 7, co-authored 7 publications receiving 1302 citations.
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Journal ArticleDOI
PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
Francisca Vazquez,Ji Hong Lim,Helen Chim,Kavita Bhalla,Geoff Girnun,Kerry A. Pierce,Clary B. Clish,Scott R. Granter,Hans R. Widlund,Bruce M. Spiegelman,Pere Puigserver +10 more
TL;DR: It is reported that the oncogenic melanocyte lineage-specification transcription factor MITF drives PGC1α (PPARGC1A) overexpression in a subset of human melanomas and derived cell lines.
Journal ArticleDOI
The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD +
Zachary Gerhart-Hines,Zachary Gerhart-Hines,John E. Dominy,Sharon M. Blättler,Mark P. Jedrychowski,Alexander S. Banks,Ji Hong Lim,Helen Chim,Steven P. Gygi,Pere Puigserver +9 more
TL;DR: A cAMP-induced phosphorylation of a highly conserved serine (S434) located in the SIRT1 catalytic domain that rapidly enhanced intrinsic deacetylase activity independently of changes in NAD(+) levels is identified.
Journal ArticleDOI
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
John E. Dominy,Yoonjin Lee,Mark P. Jedrychowski,Helen Chim,Michael J. Jurczak,Joao Paulo Camporez,Hai Bin Ruan,Jessica L. Feldman,Kerry A. Pierce,Raul Mostoslavsky,John M. Denu,Clary B. Clish,Xiaoyong Yang,Gerald I. Shulman,Steven P. Gygi,Pere Puigserver +15 more
TL;DR: It is reported that Sirt6 strongly controls PGC-1α acetylation, a key mediator of gluconeogenic gene transcription, and may be therapeutically useful for treating insulin-resistant diabetes.
Journal ArticleDOI
Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression
Yoonjin Lee,John E. Dominy,Yoon Jong Choi,Michael J. Jurczak,Nicola Tolliday,Joao Paulo Camporez,Helen Chim,Ji Hong Lim,Hai Bin Ruan,Xiaoyong Yang,Francisca Vazquez,Piotr Sicinski,Gerald I. Shulman,Pere Puigserver +13 more
TL;DR: This work reports that in mice insulin activates cyclin D1–cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression, and identifies a Cdk4 inhibitor that potently decreases PGC-1α acetylation.
Journal ArticleDOI
Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling
Sharon M. Blättler,John T. Cunningham,Francisco Verdeguer,Helen Chim,Wilhelm Haas,Huifei Liu,Klaas Romanino,Markus A. Rüegg,Steven P. Gygi,Yang Shi,Pere Puigserver +10 more
TL;DR: It is shown that chronic rapamycin treatment in mice led to insulin resistance with suppression of insulin/IGF signaling and genes associated within this pathway, such as Igf1-2, Irs1-1, and Akt1-3, and that skeletal muscle-specific YY1 knockout mice were protected fromRapamycin-induced diabetic-like symptoms.