H
Helen Grounds
Researcher at University College London
Publications - 10
Citations - 208
Helen Grounds is an academic researcher from University College London. The author has contributed to research in topics: Luciferin & Bioluminescence imaging. The author has an hindex of 6, co-authored 10 publications receiving 178 citations. Previous affiliations of Helen Grounds include University of Nottingham.
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A Dual-Color Far-Red to Near-Infrared Firefly Luciferin Analogue Designed for Multiparametric Bioluminescence Imaging
TL;DR: This work has synthesized and tested the first dual-color, far-red to near-infrared (nIR) emitting analogue of beetle luciferin, which, akin to natural lucifer in, exhibits pH dependent fluorescence spectra and emits bioluminescence of different colors with different engineered Fluc enzymes.
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Staphylococcal phenotypes induced by naturally occurring and synthetic membrane-interactive polyphenolic β-lactam resistance modifiers.
Lucia Palacios,Helena Rosado,Vicente Micol,Adriana E. Rosato,Patricia Bernal,Raquel Arroyo,Helen Grounds,James C. Anderson,Richard A. Stabler,Peter W. Taylor +9 more
TL;DR: The capacity of ECg to modify the MRSA phenotype is potentiated by stepwise removal of hydroxyl groups from the B-ring pharmacophore and the A:C fused ring system of the naturally occurring molecule.
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Convergent synthesis and optical properties of near-infrared emitting bioluminescent infra-luciferins.
James C. Anderson,Helen Grounds,Amit P. Jathoul,James A. H. Murray,Steven J. Pacman,Laurence Carlo Tisi +5 more
TL;DR: A high yielding, scalable and convergent synthesis of infra-luciferins and investigation of their potential for near-infrared bioluminescence imaging.
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Photoelectron spectroscopy of isolated luciferin and infraluciferin anions in vacuo: competing photodetachment, photofragmentation and internal conversion
Joanne L. Woodhouse,Mariana Assmann,Michael A. Parkes,Helen Grounds,Steven J. Pacman,James C. Anderson,Graham A. Worth,Helen H. Fielding +7 more
TL;DR: The electronic structure and excited-state dynamics of the ubiquitous bioluminescent probe luciferin and its furthest red-shifted analogue infraluciferin are investigated using photoelectron spectroscopy and quantum chemistry calculations and it is found that internal conversion from high-lying excited states to the S1(1ππ*) state competes efficiently with electron detachment.
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A New Oxidative Addition of Ruthenium(0) into an Aryl Halide Bond and Subsequent Intermolecular C−H Insertion
TL;DR: An unprecedented oxidative insertion of the activated ruthenium complex "Ru(CO)(PPh3)(2)" into aryl halide bonds enables a novel preparation of stable five-coordinate 16-electron d(6) sigma-aryl-Ru(II) complex Ru(CO)p-C6H4Me)Br(PPh 3)(2), which has been characterized by NMR, IR, elemental analysis, and X-ray crystallography.