Heli Matilainen

TL;DR: The expression of dominant negative caveolin in cells markedly inhibited EV1 infection, indicating the importance of caveolae for the viral replication cycle of EV1.

TL;DR: The results suggest that AcMNPV enters mammalian cells via clathrin-mediated endocytosis and possibly via macropinocytotic, which should enable future design of baculovirus vectors suitable for more specific and enhanced delivery of genetic material into mammalian cells.

TL;DR: The results imply that the efficiency of baculovirus-mediated gene delivery can be significantly enhanced in vitro when tumor-targeting ligands are used and therefore highlight the potential of b Baculov virus vectors in cancer gene therapy.

TL;DR: The results suggest that the RGD-motif is functional on the surface of baculovirus and thereby these tropism-modified viruses bind more efficiently as well as enhance the transduction efficiency of human cancer cells expressing alphaV integrins.

TL;DR: Two recombinant baculovirus vectors displaying an integrin-specific motif, RKK, as a part of two different loops of the green fluorescent protein (GFP) fused with the major envelope protein gp64 of Autographa californica M nucleopolyhedrovirus were generated.