J
Johanna Ivaska
Researcher at University of Turku
Publications - 186
Citations - 14073
Johanna Ivaska is an academic researcher from University of Turku. The author has contributed to research in topics: Integrin & Cell adhesion. The author has an hindex of 57, co-authored 172 publications receiving 11443 citations. Previous affiliations of Johanna Ivaska include Åbo Akademi University & London Research Institute.
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Journal ArticleDOI
Every step of the way: integrins in cancer progression and metastasis.
TL;DR: The contribution of integrins to the different steps of cancer progression is discussed, highlighting some of the recently identified unconventional roles ofIntegrins and novel opportunities to target integrin signalling are highlighted.
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Novel functions of vimentin in cell adhesion, migration, and signaling.
TL;DR: The implicated novel vimentin functions have broad ramifications into many different aspects of cell physiology, cellular interactions, and organ homeostasis.
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Integrins as biomechanical sensors of the microenvironment.
TL;DR: An overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering is provided, and how this biomechanical regulation allows integrins to respond to different ECM physicochemical properties and signals.
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Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
Karoliina Vuoriluoto,Hallvard Haugen,Kiviluoto S,John Mpindi,Jonna Nevo,Jonna Nevo,Christine Gjerdrum,Crina Tiron,James B. Lorens,Johanna Ivaska,Johanna Ivaska +10 more
TL;DR: It is shown that vimentin functionally contributes to EMT and is required for induction of Axl expression, and regulation of breast cancer cell migration in two- and three-dimensional matrices by vimentsin is Axl- dependent and that Axl functional contributes to lung extravasation of breast cancers cells in mice.
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CIP2A Inhibits PP2A in Human Malignancies
Melissa R. Junttila,Pietri Puustinen,Minna Niemelä,Minna Niemelä,Raija Ahola,Hugh Arnold,Trine Bøttzauw,Risto Ala-aho,Christina Nielsen,Johanna Ivaska,Johanna Ivaska,Yoichi Taya,Shi-Long Lu,Shujun Lin,Edward K. L. Chan,Xiao-Jing Wang,Reidar Grénman,Reidar Grénman,Juergen Kast,Tuula Kallunki,Rosalie C. Sears,Veli-Matti Kähäri,Veli-Matti Kähäri,Jukka Westermarck,Jukka Westermarck,Jukka Westermarck +25 more
TL;DR: The data show that CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c-Myc in human malignancies and promotes anchorage-independent cell growth and in vivo tumor formation.