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Paula Upla
Researcher at University of Jyväskylä
Publications - 13
Citations - 812
Paula Upla is an academic researcher from University of Jyväskylä. The author has contributed to research in topics: Integrin & Internalization. The author has an hindex of 9, co-authored 12 publications receiving 796 citations. Previous affiliations of Paula Upla include University of Turku.
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Journal ArticleDOI
Internalization of Echovirus 1 in Caveolae
Varpu Marjomäki,Vilja Pietiäinen,Heli Matilainen,Paula Upla,Johanna Ivaska,Liisa Nissinen,Hilkka Reunanen,Pasi Huttunen,Pasi Huttunen,Timo Hyypiä,Jyrki Heino,Jyrki Heino +11 more
TL;DR: The expression of dominant negative caveolin in cells markedly inhibited EV1 infection, indicating the importance of caveolae for the viral replication cycle of EV1.
Journal ArticleDOI
Clustering Induces a Lateral Redistribution of α2β1 Integrin from Membrane Rafts to Caveolae and Subsequent Protein Kinase C-dependent Internalization
Paula Upla,Varpu Marjomäki,Pasi Kankaanpää,Johanna Ivaska,Timo Hyypiä,F. Gisou van der Goot,Jyrki Heino +6 more
TL;DR: Alpha 2 beta 1 integrin was found inside caveolae and subsequently internalized into caveosome-like perinuclear structures, and the internalization process, unlike cluster formation or lateral redistribution, was dependent on protein kinase C alpha activity.
Journal ArticleDOI
Echovirus 1 Endocytosis into Caveosomes Requires Lipid Rafts, Dynamin II, and Signaling Events
Vilja Pietiäinen,Varpu Marjomäki,Paula Upla,Lucas Pelkmans,Lucas Pelkmans,Ari Helenius,Timo Hyypiä,Timo Hyypiä +7 more
TL;DR: Video-enhanced live microscopy revealed the rapid uptake of fluorescently labeled EV1 into mobile, intracellular structures, positive for green fluorescent protein-tagged caveolin-1, and the localization of viral RNA with endocytosed viral capsid proteins in caveosomes before initiation of viral replication.
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A Raft-derived, Pak1-regulated Entry Participates in α2β1 Integrin-dependent Sorting to Caveosomes
Mikko Karjalainen,Elina Kakkonen,Paula Upla,Heli Paloranta,Pasi Kankaanpää,Prisca Liberali,G. Herma Renkema,Timo Hyypiä,Jyrki Heino,Varpu Marjomäki +9 more
TL;DR: The results together suggest that alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes.
Journal ArticleDOI
Calpain 1 and 2 Are Required for RNA Replication of Echovirus 1
Paula Upla,Varpu Marjomäki,Liisa Nissinen,Camilla Nylund,Matti Waris,Timo Hyypiä,Jyrki Heino +6 more
TL;DR: Both calpain 1 and calpain 2 are essential for the replication of EV1 RNA, indicating that calpains are not required for virus entry but that they are important at a later stage of infection.