Helmut Klocker

TL;DR: It is shown for the first time that IL-6 is a nonsteroidal activator of the AR and that this activation is implicated in the regulation of prostate-specific proteins.

TL;DR: A previously undescribed gold nanoparticle bio-barcode assay probe for the detection of prostate specific antigen (PSA) at 330 fg/mL, automation of the assay, and the results of a clinical pilot study designed to assess the ability to detect PSA in the serum of 18 men who have undergone radical prostatectomy for prostate cancer are reported.

TL;DR: Evidence is provided that, unlike androgen-independent prostatic carcinoma cell lines, distant prostate cancer metastases do express the androgen receptor (AR) protein, which indicates that the AR may be involved in the progression of prostate cancer.

TL;DR: RASSF1A methylation 1 year after primary surgery (and during adjuvant tamoxifen therapy) was an independent predictor of poor outcome, with a relative risk for relapse of 5.1 (1.3-19.8) and for death of 6.9 ( 1.9-25.9).

TL;DR: This study shows significant increases in PCa predictive value and specificity of phi and %p2PSA compared to tPSA and %fPSA, and has limited additional value in identifying aggressive PCa.