H
Henning Birkedal-Hansen
Researcher at National Institutes of Health
Publications - 109
Citations - 14371
Henning Birkedal-Hansen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Collagenase & Matrix metalloproteinase. The author has an hindex of 52, co-authored 109 publications receiving 14045 citations. Previous affiliations of Henning Birkedal-Hansen include University of Alabama at Birmingham & Government of the United States of America.
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Journal ArticleDOI
Matrix Metalloproteinases: A Review
Henning Birkedal-Hansen,William G. I. Moore,M.K. Bodden,L.J. Windsor,B. Birkedal-Hansen,Arthur A. Decarlo,Jeffrey A. Engler +6 more
TL;DR: The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP precursors.
Journal ArticleDOI
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
Kenn Holmbeck,Paolo Bianco,John J. Caterina,Susan Yamada,Mark Kromer,Sergei A. Kuznetsov,Mahesh H. Mankani,Pamela Gehron Robey,A. Robin Poole,Isabelle Pidoux,Jerrold M. Ward,Henning Birkedal-Hansen +11 more
TL;DR: The findings demonstrate the pivotal function of MT1-MMP in connective tissue metabolism, and illustrate that modeling of the soft connective tissues matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton.
Journal ArticleDOI
Proteolytic remodeling of extracellular matrix
TL;DR: Evidence is emerging that these enzymes also play an important regulatory role in matrix remodeling by catalyzing the processing of inactive matrix metalloproteinase and cytokine precursors.
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Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.
TL;DR: In this article, the Cys73 residue is removed from the active-site zinc atom and its replacement by water, with the concomitant exposure of the active site to dithionitrobenzoate.
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Role of Matrix Metalloproteinases in Human Periodontal Diseases.
TL;DR: A body of evidence suggests that bone resorption is initiated by removal of the osteoid layer by osteoblasts by means of a collagenase-dependent process, and evidence that MMP are involved in tissue destruction in human periodontal diseases is still indirect and circumstantial.