P
Paolo Bianco
Researcher at Sapienza University of Rome
Publications - 178
Citations - 24471
Paolo Bianco is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 72, co-authored 177 publications receiving 23064 citations. Previous affiliations of Paolo Bianco include University of L'Aquila & National Institutes of Health.
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Journal ArticleDOI
Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
TL;DR: It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.
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Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays
TL;DR: The experimental origin of the concept of the population(s) referred to as mesenchymal stem cells and the experimental framework required to assess their stemness and function are revisited.
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MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
Kenn Holmbeck,Paolo Bianco,John J. Caterina,Susan Yamada,Mark Kromer,Sergei A. Kuznetsov,Mahesh H. Mankani,Pamela Gehron Robey,A. Robin Poole,Isabelle Pidoux,Jerrold M. Ward,Henning Birkedal-Hansen +11 more
TL;DR: The findings demonstrate the pivotal function of MT1-MMP in connective tissue metabolism, and illustrate that modeling of the soft connective tissues matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton.
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The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
Paolo Bianco,Xu Cao,Paul S. Frenette,Jeremy J. Mao,Pamela Gehron Robey,Paul J. Simmons,Cun-Yu Wang +6 more
TL;DR: Significant ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs, which have a major impact on their envisioned therapeutic use.
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Stem cells in tissue engineering.
Paolo Bianco,Pamela Gehron Robey +1 more
TL;DR: The identification and isolation of stem cells from a number of tissues provides appropriate targets for prospective gene therapies and has the potential to significantly alter the perspective of tissue engineering.