H
Henrik Thorlacius
Researcher at Lund University
Publications - 287
Citations - 7508
Henrik Thorlacius is an academic researcher from Lund University. The author has contributed to research in topics: Inflammation & Chemokine. The author has an hindex of 44, co-authored 276 publications receiving 6437 citations. Previous affiliations of Henrik Thorlacius include Malmö University.
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A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells.
Shahram Lavasani,Balik Dzhambazov,Mehrnaz Nouri,Frida Fåk,Sophia Buske,Göran Molin,Henrik Thorlacius,Jan Alenfall,Bengt Jeppsson,Björn Weström +9 more
TL;DR: Evidence is provided showing that the therapeutic effect of the chosen mixture of probiotic lactobacilli was associated with induction of transferable tolerogenic Tregs in MLNs, but also in the periphery and the CNS, mediated through an IL-10-dependent mechanism.
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IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality
Hong Zhang,Patrick Neuhöfer,Liang Song,Björn Rabe,Marina Lesina,Magdalena U. Kurkowski,Matthias Treiber,Thomas Wartmann,Sara Regnér,Henrik Thorlacius,Dieter Saur,Gregor Weirich,Akihiko Yoshimura,Walter Halangk,Joseph P. Mizgerd,Roland M. Schmid,Stefan Rose-John,Hana Algül +17 more
TL;DR: IL-6 trans-signaling is an essential mediator of ALI in SAP across species and it is suggested that therapeutic inhibition of IL-6 may prevent SAP-associated ALI.
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Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis
Mohammed Merza,Hannes Hartman,Milladur Rahman,Rundk Hwaiz,Enming Zhang,Erik Renström,Lingtao Luo,Matthias Mörgelin,Sara Regnér,Henrik Thorlacius +9 more
TL;DR: NETs regulate organ inflammation and injury in mice with AP, and might be targeted to reduce pancreatic tissue damage and inflammation in patients.
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Lactobacillus plantarum 299v Inhibits Escherichia coli-Induced Intestinal Permeability
Peter Mangell,Pernilla Nejdfors,Mei Wang,Siv Ahrné,Björn Weström,Henrik Thorlacius,Bengt Jeppsson +6 more
TL;DR: Pretreatment with L. plantarum 299v, which is a probiotic bacterium, protects against E. coli-induced increase in intestinal permeability, and the concept that probiotics may exert beneficial effects in the gastrointestinal tract is supported.
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Platelets support pulmonary recruitment of neutrophils in abdominal sepsis.
Muhammad Asaduzzaman,Shahram Lavasani,Milladur Rahman,Su Zhang,Oscar Ö. Braun,Bengt Jeppsson,Henrik Thorlacius +6 more
TL;DR: It is demonstrated that platelets play a key role in regulating infiltration of neutrophils and edema formation in the lung via upregulation of Mac-1 in abdominal sepsis through activation and priming circulating neutrophil for subsequent recruitment into the lung.