M
Marina Lesina
Researcher at Technische Universität München
Publications - 38
Citations - 2932
Marina Lesina is an academic researcher from Technische Universität München. The author has contributed to research in topics: Pancreatic cancer & Pancreas. The author has an hindex of 20, co-authored 37 publications receiving 2407 citations.
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Journal ArticleDOI
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Marina Lesina,Magdalena U. Kurkowski,Katharina Ludes,Stefan Rose-John,Matthias Treiber,Günter Klöppel,Akihiko Yoshimura,Wolfgang Reindl,Bence Sipos,Shizuo Akira,Roland M. Schmid,Hana Algül +11 more
TL;DR: It is established that, in addition to oncogenic Kras(G12D), IL-6 transsignaling-dependent activation of Stat3/Socs3 is required to promote PanIN progression and pancreatic ductal adenocarcinoma (PDAC).
Journal ArticleDOI
Mutant KRAS -driven cancers depend on PTPN11 /SHP2 phosphatase
Dietrich A. Ruess,Dietrich A. Ruess,Guus J.J.E. Heynen,Katrin J. Ciecielski,Jiaoyu Ai,Alexandra Berninger,Derya Kabacaoglu,Kivanc Görgülü,Zahra Dantes,S Wörmann,Kalliope N. Diakopoulos,Angeliki Faidra Karpathaki,Marlena Kowalska,Ezgi Kaya-Aksoy,Liang Song,Eveline A.N. Zeeuw van der Laan,María P. López-Alberca,Marc Nazaré,Maximilian Reichert,Dieter Saur,Mert Erkan,Ulrich T. Hopt,Bruno Sainz,Walter Birchmeier,Roland M. Schmid,Marina Lesina,Hana Algül +26 more
TL;DR: The data indicate the clinical utility of dual SHP2/MEK inhibition as a targeted therapy approach for KRAS-mutant cancers and provide evidence for a critical dependence of mutant KRAS on SHp2 during carcinogenesis.
Journal ArticleDOI
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality
Hong Zhang,Patrick Neuhöfer,Liang Song,Björn Rabe,Marina Lesina,Magdalena U. Kurkowski,Matthias Treiber,Thomas Wartmann,Sara Regnér,Henrik Thorlacius,Dieter Saur,Gregor Weirich,Akihiko Yoshimura,Walter Halangk,Joseph P. Mizgerd,Roland M. Schmid,Stefan Rose-John,Hana Algül +17 more
TL;DR: IL-6 trans-signaling is an essential mediator of ALI in SAP across species and it is suggested that therapeutic inhibition of IL-6 may prevent SAP-associated ALI.
Journal ArticleDOI
Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival
S Wörmann,Liang Song,Jiaoyu Ai,Kalliope N. Diakopoulos,Magdalena U. Kurkowski,Kivanc Görgülü,Dietrich A. Ruess,Andrew D. Campbell,Claudio Doglioni,Duncan I. Jodrell,Albrecht Neesse,Ihsan Ekin Demir,Angelica Phaedra Karpathaki,Maxim Barenboim,Maxim Barenboim,Thorsten Hagemann,Stefan Rose-John,Owen J. Sansom,Roland M. Schmid,Maria Pia Protti,Marina Lesina,Hana Algül +21 more
TL;DR: In pancreatic tumors of mice, loss of P53 function activates JAK2-STAT3 signaling, which promotes modification of the tumor stroma and tumor growth and resistance to gemcitabine.
Journal ArticleDOI
The immune network in pancreatic cancer development and progression
TL;DR: This review will try to assemble all relevant data to demonstrate the implications of the immune network on spontaneous cancer development and the role of stromal desmoplasia in this case.