L
Liang Song
Researcher at Technische Universität München
Publications - 6
Citations - 912
Liang Song is an academic researcher from Technische Universität München. The author has contributed to research in topics: Pancreatitis & Acute pancreatitis. The author has an hindex of 6, co-authored 6 publications receiving 730 citations.
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Journal ArticleDOI
Mutant KRAS -driven cancers depend on PTPN11 /SHP2 phosphatase
Dietrich A. Ruess,Dietrich A. Ruess,Guus J.J.E. Heynen,Katrin J. Ciecielski,Jiaoyu Ai,Alexandra Berninger,Derya Kabacaoglu,Kivanc Görgülü,Zahra Dantes,S Wörmann,Kalliope N. Diakopoulos,Angeliki Faidra Karpathaki,Marlena Kowalska,Ezgi Kaya-Aksoy,Liang Song,Eveline A.N. Zeeuw van der Laan,María P. López-Alberca,Marc Nazaré,Maximilian Reichert,Dieter Saur,Mert Erkan,Ulrich T. Hopt,Bruno Sainz,Walter Birchmeier,Roland M. Schmid,Marina Lesina,Hana Algül +26 more
TL;DR: The data indicate the clinical utility of dual SHP2/MEK inhibition as a targeted therapy approach for KRAS-mutant cancers and provide evidence for a critical dependence of mutant KRAS on SHp2 during carcinogenesis.
Journal ArticleDOI
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality
Hong Zhang,Patrick Neuhöfer,Liang Song,Björn Rabe,Marina Lesina,Magdalena U. Kurkowski,Matthias Treiber,Thomas Wartmann,Sara Regnér,Henrik Thorlacius,Dieter Saur,Gregor Weirich,Akihiko Yoshimura,Walter Halangk,Joseph P. Mizgerd,Roland M. Schmid,Stefan Rose-John,Hana Algül +17 more
TL;DR: IL-6 trans-signaling is an essential mediator of ALI in SAP across species and it is suggested that therapeutic inhibition of IL-6 may prevent SAP-associated ALI.
Journal ArticleDOI
Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival
S Wörmann,Liang Song,Jiaoyu Ai,Kalliope N. Diakopoulos,Magdalena U. Kurkowski,Kivanc Görgülü,Dietrich A. Ruess,Andrew D. Campbell,Claudio Doglioni,Duncan I. Jodrell,Albrecht Neesse,Ihsan Ekin Demir,Angelica Phaedra Karpathaki,Maxim Barenboim,Maxim Barenboim,Thorsten Hagemann,Stefan Rose-John,Owen J. Sansom,Roland M. Schmid,Maria Pia Protti,Marina Lesina,Hana Algül +21 more
TL;DR: In pancreatic tumors of mice, loss of P53 function activates JAK2-STAT3 signaling, which promotes modification of the tumor stroma and tumor growth and resistance to gemcitabine.
Journal ArticleDOI
Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes
Kalliope N. Diakopoulos,Marina Lesina,S Wörmann,Liang Song,Michaela Aichler,Lorenz Schild,Anna Artati,Werner Römisch-Margl,Thomas Wartmann,Robert Fischer,Yashar Kabiri,Hans Zischka,Walter Halangk,Ihsan Ekin Demir,Claudia Pilsak,Axel Walch,Christos S. Mantzoros,Jörg M. Steiner,Mert Erkan,Roland M. Schmid,Heiko Witt,Jerzy Adamski,Hana Algül +22 more
TL;DR: Dietary antioxidants, especially in combination with palm oil-derived fatty acids, blocked progression to CP and pancreatic acinar atrophy and might be used to identify therapeutic targets for CP.
Journal ArticleDOI
Interleukin-6 in inflammatory and malignant diseases of the pancreas.
TL;DR: This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis and the impact of IL/STAT pathway activation, persistent STAT3 activation and cancer immunotherapy.