H
Henry M. Rinder
Researcher at Yale University
Publications - 132
Citations - 6967
Henry M. Rinder is an academic researcher from Yale University. The author has contributed to research in topics: Platelet activation & Platelet. The author has an hindex of 39, co-authored 127 publications receiving 5856 citations. Previous affiliations of Henry M. Rinder include University of Vermont Medical Center & University of Connecticut.
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Journal ArticleDOI
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.
George Goshua,Alexander B Pine,Matthew L Meizlish,C-Hong Chang,Hanming Zhang,Parveen Bahel,Audrey Baluha,Noffar Bar,Robert D Bona,Adrienne J Burns,Charles S. Dela Cruz,Anne Dumont,Stephanie Halene,John Hwa,Jonathan L. Koff,Hope Menninger,Natalia Neparidze,Christina Price,Jonathan M. Siner,Christopher A. Tormey,Henry M. Rinder,Hyung J. Chun,Alfred Ian Lee +22 more
TL;DR: The findings show that endotheliopathy is present in COVID-19 and is likely to be associated with critical illness and death, and strategies to mitigate its progression might improve outcomes in CO VID-19.
Journal ArticleDOI
Cardiopulmonary bypass induces leukocyte-platelet adhesion.
Christine S. Rinder,Jayne L. Bonan,Henry M. Rinder,Joseph P. Mathew,Roberta Hines,Brian R. Smith +5 more
TL;DR: It is concluded that CPB, through increased platelet GMP-140 expression, causes formation of monocyte-platelet, and to a lesser extent, PMN-platelets conjugates.
Journal ArticleDOI
Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Jane C. K. Fitch,Scott A. Rollins,Louis A. Matis,Bernadette Alford,Sary F. Aranki,Charles D. Collard,Michael L. Dewar,John A. Elefteriades,Roberta Hines,Gary S. Kopf,Philip Kraker,Lan Li,Ruth O'Hara,Christine S. Rinder,Henry M. Rinder,Richard K. Shaw,Brian G. Smith,Gregory L. Stahl,Stanton K. Shernan +18 more
TL;DR: C5 inhibition significantly attenuates postoperative myocardial injury, cognitive deficits, and blood loss and suggests that C5 inhibition may represent a novel therapeutic strategy for preventing complement-mediated inflammation and tissue injury.
Journal ArticleDOI
Dynamics of leukocyte-platelet adhesion in whole blood
TL;DR: Monocytes have a competitive advantage over PMN in binding activated platelets, particularly when less potent platelet agonists are used; and platelet aggregate formation initially competes unactivated platelets off leukocytes; subsequent aggregate dissociation allows the now activated platelet to readhere to monocytes and PMN through GMP-140.
Journal ArticleDOI
Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation.
Christine S. Rinder,Henry M. Rinder,Brian R. Smith,Jane C. K. Fitch,M. Smith,Jayne B. Tracey,Louis A. Matis,Stephen P. Squinto,Scott A. Rollins +8 more
TL;DR: This model suggests that the terminal components C5a and C5b-9, but not C3a, directly contribute to platelet and neutrophil activation during extracorporeal circulation, and identifies the C5 component as a site for therapeutic intervention in cardiopulmonary bypass.