C
C-Hong Chang
Researcher at Yale University
Publications - 22
Citations - 1682
C-Hong Chang is an academic researcher from Yale University. The author has contributed to research in topics: Loop of Henle & Kidney. The author has an hindex of 14, co-authored 20 publications receiving 885 citations. Previous affiliations of C-Hong Chang include University of Cambridge & University of Edinburgh.
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Journal ArticleDOI
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.
George Goshua,Alexander B Pine,Matthew L Meizlish,C-Hong Chang,Hanming Zhang,Parveen Bahel,Audrey Baluha,Noffar Bar,Robert D Bona,Adrienne J Burns,Charles S. Dela Cruz,Anne Dumont,Stephanie Halene,John Hwa,Jonathan L. Koff,Hope Menninger,Natalia Neparidze,Christina Price,Jonathan M. Siner,Christopher A. Tormey,Henry M. Rinder,Hyung J. Chun,Alfred Ian Lee +22 more
TL;DR: The findings show that endotheliopathy is present in COVID-19 and is likely to be associated with critical illness and death, and strategies to mitigate its progression might improve outcomes in CO VID-19.
Journal ArticleDOI
A neutrophil activation signature predicts critical illness and mortality in COVID-19.
Matthew L Meizlish,Alexander B Pine,Jason Bishai,George Goshua,Emily R. Nadelmann,Michael Simonov,C-Hong Chang,Hanming Zhang,Marcus Shallow,Parveen Bahel,Kent A. Owusu,Yu Yamamoto,Tanima Arora,Deepak Atri,Amisha Patel,Rana Gbyli,Jennifer M. Kwan,Christine Won,Charles S. Dela Cruz,Christina Price,Jonathan L. Koff,Brett King,Henry M. Rinder,F. Perry Wilson,John Hwa,Stephanie Halene,William Damsky,David van Dijk,Alfred Ian Lee,Hyung J. Chun +29 more
TL;DR: In this paper, the authors carried out proteomic profiling of plasma from cross-sectional and longitudinal cohorts of hospitalized patients with COVID-19 and analyzed clinical data from a health system database of more than 3300 patients.
Journal ArticleDOI
Delayed production of neutralizing antibodies correlates with fatal COVID-19.
Carolina Lucas,Jon Klein,Maria E. Sundaram,Maria E. Sundaram,Feimei Liu,Patrick Wong,Julio Silva,Tianyang Mao,Ji Eun Oh,Subhasis Mohanty,Jiefang Huang,Maria Tokuyama,Peiwen Lu,Arvind Venkataraman,Annsea Park,Benjamin Israelow,Chantal B.F. Vogels,M. Catherine Muenker,C-Hong Chang,Arnau Casanovas-Massana,Adam J. Moore,Joseph Zell,John Fournier,Anne L. Wyllie,Melissa Campbell,Alfred Ian Lee,Hyung J. Chun,Nathan D. Grubaugh,Wade L. Schulz,Shelli F. Farhadian,Charles S. Dela Cruz,Aaron M. Ring,Albert C. Shaw,Adam V. Wisnewski,Inci Yildirim,Albert I. Ko,Saad B. Omer,Akiko Iwasaki,Akiko Iwasaki +38 more
TL;DR: In this article, the authors analyzed humoral immune responses in 229 patients with asymptomatic, mild, moderate and severe COVID-19 over time to probe the nature of antibody responses in disease severity and mortality.
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Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron
Nils O. Lindström,Melanie L. Lawrence,Sally F. Burn,Jeanette A. Johansson,Elvira R M Bakker,Rachel A. Ridgway,C-Hong Chang,Michele J. Karolak,Leif Oxburgh,Denis J. Headon,Owen J. Sansom,Ron Smits,Jamie A. Davies,Peter Hohenstein +13 more
TL;DR: It is demonstrated that the early nephron is patterned by a gradient in β-catenin activity along the axis of the nephRON tubule, which identifies a molecular network for nephrons patterning.
Journal ArticleDOI
Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19
Alexander B Pine,Matthew L Meizlish,George Goshua,C-Hong Chang,Hanming Zhang,Jason Bishai,Parveen Bahel,Amisha Patel,Rana Gbyli,Jennifer M. Kwan,Christine Won,Christina Price,Charles S. Dela Cruz,Stephanie Halene,David van Dijk,John Hwa,Alfred Ian Lee,Hyung J. Chun +17 more
TL;DR: It is demonstrated that non-critical and critical phases of CO VID-19 disease may be driven by distinct mechanisms involving key aspects of endothelial cell function, and drivers of COVID-19 pathogenesis and potential targets for future therapies are identified.