H
Hermine Deagostini-Bazin
Researcher at French Institute of Health and Medical Research
Publications - 14
Citations - 1850
Hermine Deagostini-Bazin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Neural cell adhesion molecule & Antigen. The author has an hindex of 13, co-authored 14 publications receiving 1845 citations.
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Occurrence of α2–8 linked polysialosyl units in a neural cell adhesion molecule
TL;DR: The carbohydrate and amino acid composition, and electrophoretic mobility of BSP-2 antigen correspond to those reported for a neural cell adhesion molecule (N-CAM), and methylation analysis of native and neuraminidase treated glycopeptides indicated that the sialic acid occurred as α2–8 bound polysialosyl units, similar to those of the recently described developmentally regulated polysIALosyl glycopePTides of rat brain.
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Adult and embryonic mouse neural cell adhesion molecules have different binding properties
TL;DR: It is shown here that liposomes bearing adult BSP-2 but not those bearing the embryonic form adhere to neuroblastoma cells, demonstrating that the two forms do indeed possess different binding properties.
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Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide.
TL;DR: This result indicates that cell type‐ and developmental stage‐specific glycoprotein patterns previously found in the nervous system may in part be due to different glycosylation of identical polypeptides.
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Studies on the transmembrane disposition of the neural cell adhesion molecule N-CAM. A monoclonal antibody recognizing a cytoplasmic domain and evidence for the presence of phosphoserine residues.
TL;DR: The conclusion that the N-CAM forms of higher Mr are transmembrane proteins was further corroborated by the finding that they contain phosphoserine residues, which can be labeled with (32P)phosphate in intact neuroblastoma cells.
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Monoclonal antibody against cell surface glycoprotein of neurons
TL;DR: A monoclonal antibody, named BSP-2, has been produced against glycoproteins extracted from neonatal mouse brain and its reactivity with live cells established the surface location of the antigen.