H
Hette Faber
Researcher at University Medical Center Groningen
Publications - 30
Citations - 1784
Hette Faber is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Parotid gland & Stem cell. The author has an hindex of 17, co-authored 30 publications receiving 1553 citations. Previous affiliations of Hette Faber include University of Groningen.
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Journal ArticleDOI
Rescue of salivary gland function after stem cell transplantation in irradiated glands.
Isabelle M.A. Lombaert,Jeanette F. Brunsting,Pieter K. Wierenga,Hette Faber,Monique A. Stokman,Tineke Kok,Willy H. Visser,Harm H. Kampinga,Gerald de Haan,Robert P. Coppes +9 more
TL;DR: In vivo, intra-glandular transplantation of a small number of c-Kit+ cells resulted in long-term restoration of salivary gland morphology and function and is the first proof for the potential use of stem cell transplantation to functionally rescue salivARY gland deficiency.
Journal ArticleDOI
Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer.
Peter van Luijk,Sarah Pringle,Joseph O. Deasy,Vitali Moiseenko,Hette Faber,Allan Hovan,Mirjam Baanstra,Hans Paul van der Laan,Roel G J Kierkels,Arjen van der Schaaf,Max J. H. Witjes,Jacobus M. Schippers,Jacobus M. Schippers,Sytze Brandenburg,Johannes A. Langendijk,Jonn Wu,Robert P. Coppes +16 more
TL;DR: The authors showed that it is possible to avoid irradiation of this specific area of the salivary gland region containing stem cells during therapy, which may reduce the patient’s risk of developing post-radiotherapy xerostomia.
Journal ArticleDOI
Purification and ex vivo expansion of fully functional salivary gland stem cells.
Lalitha S.Y. Nanduri,Mirjam Baanstra,Hette Faber,Cecilia Rocchi,Erik Zwart,Gerald de Haan,Ronald van Os,Robert P. Coppes +7 more
TL;DR: Using murine SG cells, single-cell self-renewal, differentiation, enrichment, enrichment of SG stem cells, and robust in vitro expansion are demonstrated, suggestive of progenitor or stem cell potency.
Journal ArticleDOI
Physiological interaction of heart and lung in thoracic irradiation
Ghazaleh Ghobadi,Sonja J. van der Veen,Beatrijs Bartelds,Rudolf A. de Boer,Michael G. Dickinson,Johan R. de Jong,Hette Faber,Maarten Niemantsverdriet,Sytze Brandenburg,Rolf M. F. Berger,Johannes A. Langendijk,Robert P. Coppes,Peter van Luijk +12 more
TL;DR: These findings show for the first time the physiological mechanism underlying the development of a multiorgan complication, RILT, and offer new opportunities to improve radiation therapy treatment of thoracic tumors, potentially facilitating increased treatment doses and tumor control.
Journal ArticleDOI
Salisphere Derived C-Kit+ Cell Transplantation Restores Tissue Homeostasis in Irradiated Salivary Gland
Lalitha S.Y. Nanduri,Isabelle M.A. Lombaert,Marianne van der Zwaag,Hette Faber,Jeanette F. Brunsting,Ronald van Os,Robert P. Coppes +6 more
TL;DR: The results show that stem cell transplantation not only rescues hypo-salivation, but also restores tissue homeostasis of the irradiated gland, necessary for long-term maintenance of adult tissue.