Showing papers by "Hideki Shirakawa published in 2005"

TL;DR: Kouchi et al. as discussed by the authors showed that deletion of EF1 and EF2 of the N-terminal four EF-hand domains caused marked reduction of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-hydrolyzing activity in vitro and loss of Ca2+ oscillation-inducing activity in mouse eggs after injection of RNA encoding the mutant.

TL;DR: PLCzeta exhibited alternative cytoplasm/nucleus localization during development, which supports the view that the sperm factor could control cell cycle-dependent generation of Ca2+ oscillations in early embryogenesis.