K
Kiyoko Fukami
Researcher at Tokyo University of Pharmacy and Life Sciences
Publications - 138
Citations - 11871
Kiyoko Fukami is an academic researcher from Tokyo University of Pharmacy and Life Sciences. The author has contributed to research in topics: Phospholipase C & Phosphatidylinositol. The author has an hindex of 52, co-authored 131 publications receiving 10921 citations. Previous affiliations of Kiyoko Fukami include Saitama Prefecture & University of Tokyo.
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Journal ArticleDOI
Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Asako Sakaue-Sawano,Hiroshi Kurokawa,Toshifumi Morimura,Aki Hanyu,Hiroshi Hama,Hatsuki Osawa,Saori Kashiwagi,Kiyoko Fukami,Takaki Miyata,Hiroyuki Miyoshi,Takeshi Imamura,Masaharu Ogawa,Hisao Masai,Atsushi Miyawaki +13 more
TL;DR: Time-lapse imaging is performed to explore the spatiotemporal patterns of cell-cycle dynamics during the epithelial-mesenchymal transition of cultured cells, the migration and differentiation of neural progenitors in brain slices, and the development of tumors across blood vessels in live mice.
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Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain.
Hiroshi Hama,Hiroshi Kurokawa,Hiroyuki Kawano,Ryoko Ando,Tomomi Shimogori,Hisayori Noda,Kiyoko Fukami,Asako Sakaue-Sawano,Atsushi Miyawaki +8 more
TL;DR: In Scale-treated mouse brain, neurons labeled with genetically encoded fluorescent proteins were visualized at an unprecedented depth in millimeter-scale networks and at subcellular resolution, suggesting that the Scale method will be useful for light microscopy–based connectomics of cellular networks in brain and other tissues.
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GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism.
TL;DR: It is suggested that GAP43, myristoylated alanine-rich C kinase substrate, and CAP23 are functionally and mechanistically related PI(4,5)P2 modulating proteins, upstream of actin and cell cortex dynamics regulation.
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ATP-dependent inositide phosphorylation required for Ca 2+ -activated secretion
Jesse C. Hay,Phillip L Fisette,Glenn H. Jenkins,Kiyoko Fukami,Tadaomi Takenawa,Richard A. Anderson,Thomas Martin +6 more
TL;DR: The results indicate that lipid kinase-mediated phosphorylation is an important basis for ATP use in the exocytotic pathway.
Journal ArticleDOI
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
Pann-Ghill Suh,Jae-Il Park,Lucia Manzoli,Lucio Cocco,Joanna C. Peak,Matilda Katan,Kiyoko Fukami,Tohru Kataoka,Sanguk Yun,Sung Ho Ryu +9 more
TL;DR: The structural organization, enzymatic properties and molecular diversity of PLC splicing variants are discussed and functional and physiological roles of each isozyme are studied.