Tatsuma Ban

TL;DR: The artificial expression of otherwise IFN-inducible DAI (DLM-1/ZBP1) in mouse fibroblasts selectively enhances the DNA-mediated induction of type I IFN and other genes involved in innate immunity, and may offer new insight into the signalling mechanisms underlying DNA-associated antimicrobial immunity and autoimmune disorders.

TL;DR: It is shown that DAI directly interacts with DNA in vitro and that it requires three DNA-binding domains for full activation in vivo and that the artificially induced dimerization of DAI results in the DNA-independent activation of type I IFN genes, thereby providing a better understanding for the molecular basis ofDAI activation.

TL;DR: It is shown that during IRF8-dependent monocyte differentiation, IRf8 binding occurs at both promoter-proximal and promotor-distal regions together with the transcription factor PU and is associated with gene induction.

TL;DR: Current knowledge of the function of HMGB proteins, as a ligand that can evoke inflammatory responses, and as a sensor for nucleic-acid-mediated immune responses is summarized.

TL;DR: Irf8(-/-) haematopoietic progenitors not only bestows monocyte and DC differentiation potential upon mononuclear phagocytes but also restrains these progenitor from differentiating into neutrophils.