M
Mitsuharu Sato
Researcher at University of Tokyo
Publications - 23
Citations - 6532
Mitsuharu Sato is an academic researcher from University of Tokyo. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 23, co-authored 23 publications receiving 6207 citations. Previous affiliations of Mitsuharu Sato include Osaka University.
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Journal ArticleDOI
IRF-7 is the master regulator of type-I interferon-dependent immune responses
Kenya Honda,Hideyuki Yanai,Hideo Negishi,Masataka Asagiri,Mitsuharu Sato,Tatsuaki Mizutani,Naoya Shimada,Yusuke Ohba,Yusuke Ohba,Akinori Takaoka,Nobuaki Yoshida,Tadatsugu Taniguchi +11 more
TL;DR: It is shown that mice deficient in the Irf7 gene are more vulnerable than Myd88-/- mice to viral infection, and this correlates with a marked decrease in serum IFN levels, indicating the importance of the IRF-7-dependent induction of systemic IFN responses for innate antiviral immunity.
Journal ArticleDOI
Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
Mitsuharu Sato,Hirofumi Suemori,Naoki Hata,Masataka Asagiri,Kouetsu Ogasawara,Kazuki Nakao,Takeo Nakaya,Motoya Katsuki,Shigeru Noguchi,Nobuyuki Tanaka,Tadatsugu Taniguchi +10 more
TL;DR: The results demonstrate the essential and distinct roles of the two factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response.
Journal ArticleDOI
Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
TL;DR: Results indicate that IRF‐7 is a key factor in the positive feedback regulation of IFN‐β/β production, and in cells lacking p48, an essential component ofIFN stimulated gene factor 3 (ISGF3).
Journal ArticleDOI
Multistage regulation of Th1-type immune responses by the transcription factor IRF-1.
Shinsuke Taki,Takeo Sato,Kouetsu Ogasawara,Taeko Fukuda,Mitsuharu Sato,Shigeaki Hida,Gen Suzuki,Masao Mitsuyama,Eun Hee Shin,Soumei Kojima,Tadatsugu Taniguchi,Yoshihiro Asano +11 more
TL;DR: It is shown that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro, indicating the involvement of IRf-1 in multiple stages of the Th1 limb of the immune response.
Journal ArticleDOI
Cross Talk Between Interferon-γ and -α/β Signaling Components in Caveolar Membrane Domains
Akinori Takaoka,Yukiko Mitani,Hirofumi Suemori,Mitsuharu Sato,Taeko Yokochi,Shigeru Noguchi,Nobuyuki Tanaka,Tadatsugu Taniguchi +7 more
TL;DR: Induction of cellular responses to cytokines often involves cross-communication through their respective receptors, and here, signaling by interferon-gamma (IFN-Gamma) is shown to depend on the IFN-alpha/beta receptor components.