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Hilary Koprowski

Researcher at Thomas Jefferson University

Publications -  336
Citations -  25417

Hilary Koprowski is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Virus & Antigen. The author has an hindex of 80, co-authored 336 publications receiving 24997 citations. Previous affiliations of Hilary Koprowski include World Health Organization & Niigata University.

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Routine immunization with orally administered attenuated poliovirus. A study of 850 children in an American city.

TL;DR: The present study explored the feasibility of early immunization of normal children living in a low-income area of an American city and found the vaccines were efficacious, according to serologic evidence, in conferring immunity to poliomyelitis.
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Acute demyelinating disease in a chimpanzee three years after inoculation of brain cells from a patient with MS

TL;DR: Brain cells from a patient with classic multiple sclerosis were inoculated intracerebrally into the frontal lobe of a newborn chimpanzee and the animal developed acute quadriplegia three years, two months later and was killed four days after the onset of symptoms.
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Persistence of antibodies after vaccination with living attenuated poliovirus.

TL;DR: Tests for neutralizing antibodies showed that neither the young age of some of the infants nor their possession of transplacental antibodies had any discernible effect on antibody levels after vaccination and that the seven children in group A (who received the rodent adapted TN type 2 virus) all had type 2 antibody titers ranging from 1:16 to 1:256 approximately eight years after the vaccination.
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The nerve growth factor receptor in normal and transformed neural crest cells.

TL;DR: To allow a more definitive molecular weight assignment of the NGF receptor, a prepared anti-NGF receptor monoclonal antibody (MAb) was prepared.
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A new test of the reproductive capacity temperature marker of poliovirus: the limited thermal exposure test.

TL;DR: Following the exposure of infected monolayers to increased temperatures for short periods, virulent, rct 40+ strains frequently showed an increase in plaque counts, indicating that the LTE test is less sensitive to variations in incubation temperature than other tests.