H
Hillel Haim
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 37
Citations - 1220
Hillel Haim is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Viral entry & Virus. The author has an hindex of 15, co-authored 30 publications receiving 1023 citations. Previous affiliations of Hillel Haim include Harvard University & Veterans Health Administration.
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Journal ArticleDOI
Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state.
Hillel Haim,Zhihai Si,Navid Madani,Liping Wang,Joel R. Courter,Amy M. Princiotto,Aemro Kassa,Marciela M. DeGrace,Kathleen McGee-Estrada,Megan Mefford,Dana Gabuzda,Amos B. Smith,Joseph Sodroski +12 more
TL;DR: The ability of soluble CD4 mimics to inactivate HIV-1 by prematurely triggering active but transient intermediate states of the envelope glycoproteins is demonstrated.
Journal ArticleDOI
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer
Youdong Mao,Liping Wang,Christopher Gu,Alon Herschhorn,Shi Hua Xiang,Hillel Haim,Xinzhen Yang,Joseph Sodroski,Joseph Sodroski +8 more
TL;DR: An ~11-Å cryo-EM structure of the trimeric HIV-1 Env precursor in its unliganded state is described, which consists of a cage-like structure with an interior void surrounding the trimer axis and restricts antibody access.
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Phenotypic and Immunologic Comparison of Clade B Transmitted/Founder and Chronic HIV-1 Envelope Glycoproteins
Craig B. Wilen,Nicholas F. Parrish,Jennifer M. Pfaff,Julie M. Decker,Elizabeth A. Henning,Hillel Haim,Josiah Petersen,Jason A. Wojcechowskyj,Joseph Sodroski,Barton F. Haynes,David C. Montefiori,John C. Tilton,George M. Shaw,Beatrice H. Hahn,Robert W. Doms +14 more
TL;DR: There are subtle but significant structural differences between T/F and chronic clade B Envs that may have implications for HIV-1 transmission and the design of effective vaccines.
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Contribution of Intrinsic Reactivity of the HIV-1 Envelope Glycoproteins to CD4-Independent Infection and Global Inhibitor Sensitivity
Hillel Haim,Bettina Strack,Aemro Kassa,Navid Madani,Liping Wang,Joel R. Courter,Amy M. Princiotto,Kathleen McGee,Beatriz Pacheco,Michael S. Seaman,Amos B. Smith,Joseph Sodroski +11 more
TL;DR: Quantitative differences in intrinsic reactivity contribute to HIV-1 strain variability in global susceptibility to neutralization and explain the long-observed relationship between increased inhibitor sensitivity and decreased entry requirements for target cell CD4.
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Proteolytic Processing of the Human Immunodeficiency Virus Envelope Glycoprotein Precursor Decreases Conformational Flexibility
TL;DR: Apparently, proteolytic processing of the HIV-1 Env precursor decreases conformational flexibility of the Env trimeric complex, differentially affecting the integrity/accessibility of epitopes for neutralizing and nonneutralizing antibodies.