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Beatriz Pacheco
Researcher at Harvard University
Publications - 29
Citations - 1243
Beatriz Pacheco is an academic researcher from Harvard University. The author has contributed to research in topics: Gp41 & Virus. The author has an hindex of 19, co-authored 29 publications receiving 1090 citations. Previous affiliations of Beatriz Pacheco include Autonomous University of Madrid & Spanish National Research Council.
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Journal ArticleDOI
Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions
Andrés Finzi,Shi Hua Xiang,Beatriz Pacheco,Liping Wang,Jessica Haight,Aemro Kassa,Brenda Danek,Marie Pancera,Peter D. Kwong,Joseph Sodroski +9 more
TL;DR: Despite lack of contact with CD4, the gp120 inner-domain layers govern CD4 triggering by participating in conformational transitions within gp120 and regulating the interaction with gp41.
Journal ArticleDOI
Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance.
TL;DR: Novel nucleoside/nucleotide analogs in advanced clinical trials include phosphonates similar to adefovir or ten ofovir, and new tenofovir derivatives with improved pharmacological properties.
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Contribution of Intrinsic Reactivity of the HIV-1 Envelope Glycoproteins to CD4-Independent Infection and Global Inhibitor Sensitivity
Hillel Haim,Bettina Strack,Aemro Kassa,Navid Madani,Liping Wang,Joel R. Courter,Amy M. Princiotto,Kathleen McGee,Beatriz Pacheco,Michael S. Seaman,Amos B. Smith,Joseph Sodroski +11 more
TL;DR: Quantitative differences in intrinsic reactivity contribute to HIV-1 strain variability in global susceptibility to neutralization and explain the long-observed relationship between increased inhibitor sensitivity and decreased entry requirements for target cell CD4.
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A V3 Loop-Dependent gp120 Element Disrupted by CD4 Binding Stabilizes the Human Immunodeficiency Virus Envelope Glycoprotein Trimer
Shi Hua Xiang,Andrés Finzi,Beatriz Pacheco,Kevin M. Alexander,Wen Yuan,Carlo D. Rizzuto,Chih Chin Huang,Peter D. Kwong,Joseph Sodroski +8 more
TL;DR: It is shown that insertions in the V3 stem or polar substitutions in a conserved hydrophobic patch near the V 3 tip result in decreased gp120-gp41 association and decreased chemokine receptor binding (in the CD4-bound state).
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Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins
Jonathan Richard,Beatriz Pacheco,Neelakshi Gohain,Maxime Veillette,Shilei Ding,Nirmin Alsahafi,William D. Tolbert,Jérémie Prévost,Jean-Philippe Chapleau,Mathieu Coutu,Manxue Jia,Nathalie Brassard,Jongwoo Park,Joel R. Courter,Bruno Melillo,Loïc Martin,Cécile Tremblay,Beatrice H. Hahn,Daniel Kaufmann,Xueling Wu,Amos B. Smith,Joseph Sodroski,Marzena Pazgier,Andrés Finzi,Andrés Finzi +24 more
TL;DR: Test whether small CD4-mimetics able to “push” Env into this conformation sensitize HIV-1-infected cells to ADCC mediated by HIV + sera and results indicate that CD4mc initially open the trimeric Env enough to allow the binding of CoRBS antibodies but not anti-cluster A antibodies.