J
John C. Tilton
Researcher at Case Western Reserve University
Publications - 39
Citations - 3228
John C. Tilton is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Virus & Immune system. The author has an hindex of 23, co-authored 38 publications receiving 2752 citations. Previous affiliations of John C. Tilton include National Institutes of Health & Heidelberg University.
Papers
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Journal ArticleDOI
HIV: Cell Binding and Entry
TL;DR: An overview into the mechanism of HIV entry is provided, historical context to key discoveries, discuss recent advances, and speculate on future directions in the field.
Journal ArticleDOI
Entry inhibitors in the treatment of HIV-1 infection
John C. Tilton,Robert W. Doms +1 more
TL;DR: A review of the entry inhibitors and their use in the management of HIV-1 infection forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development.
Journal ArticleDOI
Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+ T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2
Christiana Iyasere,John C. Tilton,Alison J. Johnson,Souheil Antoine Younes,Bader Yassine-Diab,Rafick Pierre Sekaly,William W. Kwok,Stephen A. Migueles,Alisha C. Laborico,W. Lesley Shupert,Claire W. Hallahan,Richard T. Davey,Mark Dybul,S Vogel,Julia A. Metcalf,Mark Connors +15 more
TL;DR: Low frequencies of HIV-specific CD4+ T cells persist in the peripheral blood during viremia, are not replicatively senescent, and proliferate when IL-2 is provided exogenously.
Journal ArticleDOI
Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)
Philipp Eissmann,Lisa Beauchamp,Lisa Beauchamp,Joe Wooters,Joe Wooters,John C. Tilton,John C. Tilton,Eric O. Long,Eric O. Long,Carsten Watzl,Carsten Watzl +10 more
TL;DR: The molecular basis for the different signals generated by 2B4 is investigated, showing that the first immunoreceptor tyrosine-based switch motif (ITSM) within the cytoplasmic tail of 2 B4 is sufficient for2B4-mediated NK-cell activation, whereas the third ITSM can negatively influence 2B 4 signaling.
Book ChapterDOI
Molecular mechanisms of HIV entry.
TL;DR: Understanding of HIV entry has led to the development of successful small molecule inhibitors for the clinical treatment of HIV infection as well as insights into viral tropism and pathogenesis.