H
Hilmar Lemke
Researcher at University of Kiel
Publications - 47
Citations - 11324
Hilmar Lemke is an academic researcher from University of Kiel. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 23, co-authored 47 publications receiving 10998 citations.
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Journal Article
Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.
TL;DR: The data suggest that the early stages of mitogen stimulation represent initial sequences of proliferation and not parts of the cell cycle, and immunostaining with monoclonal antibody Ki-67 provides a reliable means of rapidly evaluating the growth fraction of normal and neoplastic human cell populations.
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Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation
TL;DR: A first series of immunostainings of tumour biopsies indicated that Ki‐67 may be a potent tool for easy and quick evaluation of the proportion of proliferating cells in a tumour.
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The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.
Harald Stein,D Y Mason,Johannes Gerdes,N O'Connor,J. S. Wainscoat,Gorm Pallesen,K C Gatter,B Falini,Georges Delsol,Hilmar Lemke,R Schwarting,Karl Lennert +11 more
TL;DR: Results obtained indicate that Ki-1 antigen is an inducible lymphoid-associated molecule that identifies a group of hitherto poorly characterized normal and neoplastic large lymphoid cells in Hodgkin's disease and Disorders in which only a minority of cells express Ki- 1 antigen probably represent lesions in whichonly some of the abnormal cells have transformed into an "activation state.
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Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells
Ulrich Schwab,Harald Stein,J. Gerdes,Hilmar Lemke,Hartmut Kirchner,Michael Schaadt,Volker Diehl +6 more
TL;DR: Production of mouse monoclonal antibodies against the Hodgkin cell line L428 was described and one hybridoma antibody was found to be specific for H and SR cells of all Hodgkin's lymphomas tested and a minute, but distinct new cell population in normal tonsils and lymph nodes.
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Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population
Harald Stein,Johannes Gerdes,Ulrich Schwab,Hilmar Lemke,David Y. Mason,Andreas Ziegler,Wolfgang Schienle,Volker Diehl +7 more
TL;DR: It is suggested that the hitherto unknown cell population detected with the monoclonal antibody Ki‐I in normal lymphoid tissue is the normal equivalent of H and SR cells.