https://onlinelibrary.wiley.com/doi/pdf/10.1002/EXP.20210005

Nanozyme for tumor therapy: Surface modification matters

Background There is an increased consumer demand for products derived from natural sources or containing natural compounds used to preserve or improve food quality and/or human health. Carvacrol and thymol, two phenolic, monoterpene isomers, extracted from natural sources such as oregano and thyme, showed antioxidant, antimicrobial, antihypertensive, immunomodulatory and anticancer properties. They have also had applications in functional food formulations, influenced food quality and positively affected human health. Scope and approach This review aims to cover the most recent findings related to bioactivities of carvacrol and thymol along with their mode of impact on human health and food systems. It also covers the recent applications of carvacrol and thymol with food products, and as nutraceuticals. Their possible use against SARS-CoV-2 virus and on human health are also reviewed. Key findings and conclusions Recently, carvacrol and thymol have been successfully used in products, showing the potential to extend the shelf-life of various foods. Moreover, both compounds showed a positive impact on human health and are considered safe for consumption. Carvacrol has also been reported to have antiviral properties, while in silico analyses suggested they can be used as supportive drugs for combating the SARS-CoV-2 virus.

Biological activity of plant-based carvacrol and thymol and their impact on human health and food quality

Air pollution consists of highly variable and complex mixtures recognized as major contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled with limitations surrounding epidemiological and animal studies, has necessitated the development of new approach methods (NAMs) to evaluate air pollution toxicity. These alternative approaches include in vitro (cell-based) models, wherein toxicity of test atmospheres can be evaluated with increased efficiency compared to in vivo studies. In vitro exposure systems have recently been developed with the goal of evaluating air pollutant-induced toxicity; though the specific design parameters implemented in these NAMs-based studies remain in flux. This review aims to outline important design parameters to consider when using in vitro methods to evaluate air pollutant toxicity, with the goal of providing increased accuracy, reproducibility, and effectiveness when incorporating in vitro data into human health evaluations. This review is unique in that experimental considerations and lessons learned are provided, as gathered from first-hand experience developing and testing in vitro models coupled to exposure systems. Reviewed design aspects include cell models, cell exposure conditions, exposure chambers, and toxicity endpoints. Strategies are also discussed to incorporate in vitro findings into the context of in vivo toxicity and overall risk assessment.

New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing.

Baicalin mediated regulation of key signaling pathways in cancer

Fabrication, characterization, physicochemical stability and simulated gastrointestinal digestion of pterostilbene loaded zein-sodium caseinate-fucoidan nanoparticles using pH-driven method

Physico-chemical characterization of carvacrol loaded zein nanoparticles for enhanced anticancer activity and Investigation of molecular interactions between them by molecular docking

Synthesis of luteolin loaded zein nanoparticles for targeted cancer therapy improving bioavailability and efficacy

MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFR/Akt/GSK3β/β-catenin pathway: Amelioration by fisetin

Designing of fatty acid-surfactant conjugate based nanomicelles of morin hydrate for simultaneously enhancing anticancer activity and oral bioavailability.

Hina Agraval

Papers

Physico-chemical characterization of carvacrol loaded zein nanoparticles for enhanced anticancer activity and Investigation of molecular interactions between them by molecular docking

Synthesis of luteolin loaded zein nanoparticles for targeted cancer therapy improving bioavailability and efficacy

MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFR/Akt/GSK3β/β-catenin pathway: Amelioration by fisetin

Designing of fatty acid-surfactant conjugate based nanomicelles of morin hydrate for simultaneously enhancing anticancer activity and oral bioavailability.

Baicalin encapsulating lipid-surfactant conjugate based nanomicelles: Preparation, characterization and anticancer activity.