H
Hiroaki Hemmi
Researcher at Osaka University
Publications - 27
Citations - 26000
Hiroaki Hemmi is an academic researcher from Osaka University. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 22, co-authored 22 publications receiving 24813 citations.
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Journal ArticleDOI
Differential contribution of osteoclast- and osteoblast-lineage cells to CpG-oligodeoxynucleotide (CpG-ODN) modulation of osteoclastogenesis.
TL;DR: CpG‐ODNs modulate osteoclast differentiation through Toll‐like receptor 9 (TLR9) through activation of TLR9 on both osteocline precursors and osteoblasts and is found to be more important for this activity than Osteoclastic TLR 9.
Journal ArticleDOI
Direct injection of plasmid DNA into the skin induces dermatitis by activation of monocytes through toll-like receptor 9.
Daisuke Sawamura,Riichiro Abe,Maki Goto,Masashi Akiyama,Hiroaki Hemmi,Shizuo Akira,Hiroshi Shimizu +6 more
TL;DR: This study examined whether the application of plasmid DNA by direct injection induces any adverse skin effects after direct injection of naked DNA into skin.
Journal ArticleDOI
Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis
Izumi Sasaki,Takashi Kato,Hiroaki Hemmi,Yuri Fukuda-Ohta,Naoko Wakaki-Nishiyama,Asumi Yamamoto,Tsuneyasu Kaisho +6 more
TL;DR: Homeostatic roles of conventional type 1 DC, cDC1, are reviewed, focusing upon intestinal immunity, and it is revealed that c DC1 are critical for maintaining intestinal immune homeostasis.
Posted ContentDOI
TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
Takuma Shibata,Ryota Sato,Masato Taoka,Shin-ichiroh Saitoh,Mayumi Komine,Ken Yamaguchi,Susumu Goyama,Yuji Motoi,Jiro Kitaura,Kumi Izawa,Yoshio Yamaguchi,Yumiko Tsukamoto,Takeshi Ichinohe,Etsuko Fujita,Ryosuke Hiranuma,Ryutaro Fukui,Yoichi Furukawa,Toshio Kitamura,Toshiyuki Takai,Arinobu Tojo,Mamitaro Ohtsuki,Umeharu Ohto,Toshiyuki Shimizu,Manabu Ozawa,Nobuaki Yoshida,Toshiaki Isobe,Eicke Latz,Kojiro Mukai,Tomohiko Taguchi,Hiroaki Hemmi,Shizuo Akira,Kensuke Miyake +31 more
TL;DR: In this paper , the authors demonstrated that TLR7/8 responses to lysosomal nucleoside stress drive SLC29A3 disorders in mice and showed that increased phagocyte numbers were associated with increased nucleosid storage and increased proliferation.
Journal ArticleDOI
Tmem45b is essential for inflammation- and tissue injury–induced mechanical pain hypersensitivity
Tadashi Tanioku,Masayuki Nishibata,Yasuyuki Tokinaga,Kohtarou Konno,Masahiko Watanabe,Hiroaki Hemmi,Yuri Fukuda-Ohta,Tsuneyasu Kaisho,Hidemasa Furue,Tomoyuki Kawamata +9 more
TL;DR: In this paper , the authors showed that the chemical ablation of isolectin B4-binding (IB4+) afferents suppressed inflammation and tissue injury-induced mechanical pain hypersensitivity.