T
Toshiyuki Takai
Researcher at Tohoku University
Publications - 311
Citations - 20143
Toshiyuki Takai is an academic researcher from Tohoku University. The author has contributed to research in topics: Receptor & Immune system. The author has an hindex of 70, co-authored 295 publications receiving 18599 citations. Previous affiliations of Toshiyuki Takai include Kansai Medical University & Randall's Food Markets.
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Journal ArticleDOI
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.
Masaharu Noda,Shin Shimizu,Tsutomu Tanabe,Toshiyuki Takai,Toshiaki Kayano,Takayuki Ikeda,Hideo Takahashi,Hitoshi Nakayama,Yuichi Kanaoka,Naoto Minamino,Kenji Kangawa,Hisayuki Matsuo,Michael A. Raftery,Tadaaki Hirose,Seiichi Inayama,Hidenori Hayashida,Takashi Miyata,Shosaku Numa +17 more
TL;DR: Cloning and sequence analysis of cDNA for the Electrophorus electricus electroplax sodium channel indicate that this protein exhibits four repeated homology units, which are presumably oriented in a pseudosymmetric fashion across the membrane.
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Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought conditions
Yusaku Uga,Kazuhiko Sugimoto,Satoshi Ogawa,Satoshi Ogawa,Jagadish Rane,Jagadish Rane,Manabu Ishitani,Naho Hara,Yuka Kitomi,Yuka Kitomi,Yoshiaki Inukai,Kazuko Ono,Noriko Kanno,Haruhiko Inoue,Hinako Takehisa,Ritsuko Motoyama,Yoshiaki Nagamura,Jianzhong Wu,Takashi Matsumoto,Toshiyuki Takai,Kazutoshi Okuno,Masahiro Yano +21 more
TL;DR: It is demonstrated that alteration of root system architecture improves drought avoidance through the cloning and characterization of DEEPER ROOTING 1 (DRO1), a rice quantitative trait locus controlling root growth angle.
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Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
Masayoshi Mishina,Toshiyuki Takai,Keiji Imoto,Masaharu Noda,Tomoyuki Takahashi,Shosaku Numa,Christoph Methfessel,Bert Sakmann +7 more
TL;DR: The conductance and gating properties of the two classes of channels suggest that replacement of the γ-subunit by the ε- subunit is responsible for the functional alteration of the receptor during muscle development.
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Augmented humoral and anaphylactic responses in FcγRII-deficient mice
TL;DR: It is demonstrated that FcγRII acts as a general negative regulator of immune-complex-triggered activation in vivo for both the afferent and efferent limbs of the immune response.
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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
Takako Koga,Masanori Inui,Kazuya Inoue,Sunhwa Kim,Ayako Suematsu,Ayako Suematsu,Ayako Suematsu,Eiji Kobayashi,Toshio Iwata,Hiroshi Ohnishi,Takashi Matozaki,Tatsuhiko Kodama,Tadatsugu Taniguchi,Hiroshi Takayanagi,Hiroshi Takayanagi,Hiroshi Takayanagi,Toshiyuki Takai +16 more
TL;DR: It is shown that mice lacking immunoreceptor tyrosine-based activation motif (ITAM)-harbouring adaptors, Fc receptor common γ subunit (FcRγ) and DNAX-activating protein (DAP)12, exhibit severe osteopetrosis owing to impaired osteoclast differentiation.