T
Takeshi Ichinohe
Researcher at University of Tokyo
Publications - 56
Citations - 5852
Takeshi Ichinohe is an academic researcher from University of Tokyo. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 30, co-authored 52 publications receiving 4963 citations. Previous affiliations of Takeshi Ichinohe include Tokyo University of Science & National Institutes of Health.
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Journal ArticleDOI
Microbiota regulates immune defense against respiratory tract influenza A virus infection
Takeshi Ichinohe,Iris K. Pang,Yosuke Kumamoto,David R. Peaper,John Hsi En Ho,Thomas S. Murray,Thomas S. Murray,Akiko Iwasaki +7 more
TL;DR: It is found that neomycin-sensitive bacteria are associated with the induction of productive immune responses in the lung and local or distal injection of Toll-like receptor (TLR) ligands could rescue the immune impairment in the antibiotic-treated mice.
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Inflammasome recognition of influenza virus is essential for adaptive immune responses
TL;DR: It is demonstrated that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus.
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Influenza virus activates inflammasomes via its intracellular M2 ion channel
TL;DR: The results show a mechanism by which influenza virus infection activates inflammasomes and identify the sensing of disturbances in intracellular ionic concentrations as a previously unknown pathogen-recognition pathway.
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Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome
TL;DR: Direct evidence is provided that SARS-CoV 3a protein activates the NLRP3 inflammasome in lipopolysaccharide-primed macrophages, highlighting the importance of viroporins, transmembrane pore-forming viral proteins, in virus-induced NLRP2 inflammaome activation.
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Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I
Hideki Hasegawa,Hirofumi Sawa,Martha J. Lewis,Martha J. Lewis,Yasuko Orba,Noreen Sheehy,Yoshie Yamamoto,Takeshi Ichinohe,Yasuko Tsunetsugu-Yokota,Harutaka Katano,Hidehiro Takahashi,Junichiro Matsuda,Tetsutaro Sata,Takeshi Kurata,Kazuo Nagashima,William W. Hall +15 more
TL;DR: The generation of HTLV-I Tax transgenic mice is described using the Lck proximal promoter to restrict transgene expression to developing thymocytes and this model accurately reproduces human disease and will provide a tool for analysis of the molecular events in transformation and for the development of new therapeutics.