Ryutaro Fukui

TL;DR: It is suggested that dsRNA in commensal bacteria contributes to anti-inflammatory and protective immune responses and is identified as a discriminatory sensor to small intestinal commensals by using Toll-like receptor 3.

TL;DR: The results suggest that PRAT4A regulates the subcellular distribution and response of multiple TLRs and is required for both innate and adaptive immune responses.

TL;DR: It is demonstrated that mice harboring a D34A mutation showed TLR7-dependent, systemic lethal inflammation and CD4(+) T cells showed marked differentiation toward T helper 1 (Th1) or Th17 cell subsets and B cell depletion abolished T cell differentiation and systemic inflammation.

TL;DR: It is shown that TLR7 and 9 are inversely linked by Unc93B1, a multiple membrane-spanning endoplasmic reticulum (ER) protein, and collectively, TLR response to nucleic acids in DCs is biased toward DNA-sensing by Unc 93B1.

TL;DR: It is shown that DNase II is required for TLR9 activation by bacterial genomic DNA, and test two types ofTLR9 ligands, CpG-A and C pG-B, and demonstrate that TLR 9 responds to DNA fragments generated by DNaseII.