H
Hiroaki Kitaoka
Researcher at Kōchi University
Publications - 168
Citations - 2679
Hiroaki Kitaoka is an academic researcher from Kōchi University. The author has contributed to research in topics: Hypertrophic cardiomyopathy & Heart failure. The author has an hindex of 26, co-authored 146 publications receiving 2158 citations.
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Journal ArticleDOI
Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes.
Yuichi Baba,Jason K. Higa,Briana K. Shimada,Kate M. Horiuchi,Tomohiro Suhara,Tomohiro Suhara,Motoi Kobayashi,Jonathan D. Woo,Hiroko Aoyagi,Karra S. Marh,Hiroaki Kitaoka,Takashi Matsui +11 more
TL;DR: The findings suggest that ferroptosis is a significant type of cell death in CMs and that mTOR plays an important role in protecting CMs against excess iron and ferroPTosis, at least in part, by regulating ROS production.
Journal ArticleDOI
Comparison of prevalence of apical hypertrophic cardiomyopathy in Japan and the United States.
TL;DR: The morphologic apical form of hypertrophic cardiomyopathy (HC), in which left ventricular (LV) wall thickening is confined to the most distal region at the apex, has been regarded as a phenotypic expression of nonobstructive HC largely unique to Japanese patients.
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International External Validation Study of the 2014 European Society of Cardiology Guidelines on Sudden Cardiac Death Prevention in Hypertrophic Cardiomyopathy (EVIDENCE-HCM)
Constantinos O'Mahony,Constantinos O'Mahony,Fatima Jichi,Steve R. Ommen,Imke Christiaans,Eloisa Arbustini,Pablo García-Pavía,Pablo García-Pavía,Franco Cecchi,Iacopo Olivotto,Hiroaki Kitaoka,Israel Gotsman,Gerald Carr-White,Jens Mogensen,Loizos Antoniades,Saidi A Mohiddin,Saidi A Mohiddin,Saidi A Mohiddin,Mathew S. Maurer,Hak Chiaw Tang,Jeffrey B. Geske,Konstantinos C. Siontis,Konstantinos C. Siontis,Karim D. Mahmoud,Karim D. Mahmoud,Alexa M.C. Vermeer,Arthur Wilde,Valentina Favalli,Oliver P Guttmann,Oliver P Guttmann,María Gallego-Delgado,Fernando Domínguez,Ilaria Tanini,Toru Kubo,Andre Keren,Teofila Bueser,Teofila Bueser,Sarah Waters,Issa Farah Issa,James Malcolmson,James Malcolmson,James Malcolmson,Tom Burns,Neha Sekhri,Neha Sekhri,Neha Sekhri,Christopher W. Hoeger,Rumana Z Omar,Perry M. Elliott +48 more
TL;DR: This study confirms that the HCM Risk-SCD model provides accurate prognostic information that can be used to target implantable cardioverter defibrillator therapy in patients at the highest risk of SCD.
Journal ArticleDOI
Lifelong left ventricular remodeling of hypertrophic cardiomyopathy caused by a founder frameshift deletion mutation in the cardiac Myosin-binding protein C gene among Japanese.
Toru Kubo,Hiroaki Kitaoka,Makoto Okawa,Yoshihisa Matsumura,Nobuhiko Hitomi,Naohito Yamasaki,Takashi Furuno,Jun Takata,Masanori Nishinaga,Akinori Kimura,Yoshinori Doi +10 more
TL;DR: Elderly patients with a V592fs/8 mutation in the MyBPC gene may evolve into the "end-stage" HCM, characterized by left ventricular systolic dysfunction, cavity dilation, and irreversible heart failure.
Journal ArticleDOI
Significance of high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy
Toru Kubo,Hiroaki Kitaoka,Shigeo Yamanaka,Takayoshi Hirota,Yuichi Baba,Kayo Hayashi,Tatsuo Iiyama,Naoko Kumagai,Katsutoshi Tanioka,Naohito Yamasaki,Yoshihisa Matsumura,Takashi Furuno,Tetsuro Sugiura,Yoshinori Doi +13 more
TL;DR: In patients with HCM, an abnormal serum concentration of hs-cTnT is an independent predictor of adverse outcome, and a higher degree of abnormality in hs -cTNT value is associated with a greater risk of cardiovascular events.