H
Hirohei Yamamura
Researcher at Kobe University
Publications - 34
Citations - 2773
Hirohei Yamamura is an academic researcher from Kobe University. The author has contributed to research in topics: Tyrosine phosphorylation & Tyrosine kinase. The author has an hindex of 20, co-authored 34 publications receiving 2741 citations. Previous affiliations of Hirohei Yamamura include National Institutes of Health & American Cyanamid.
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Journal ArticleDOI
Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.
Minoru Takata,H. Sabe,Akiko Hata,T. Inazu,Yukio Homma,T. Nukada,Hirohei Yamamura,Tomohiro Kurosaki +7 more
TL;DR: It is demonstrated that Syk mediates IP3 generation, whereas Lyn regulates Ca2+ mobilization through a process independent of IP3generation, despite the normal kinetics ofIP3 turnover.
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Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.
TL;DR: Study of Syk mutants in B cells made Syk deficient by homologous recombination knockout confirms that both SH2 domains are necessary for Syk binding to tyrosine-phosphorylated Ig alpha and Ig beta and indicates that this binding is necessary forSyk (Y518/519) phosphorylation after BCR ligation.
Journal ArticleDOI
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
Tomohiro Kurosaki,Minoru Takata,Y Yamanashi,T. Inazu,T Taniguchi,Tadashi Yamamoto,Hirohei Yamamura +6 more
TL;DR: Results suggest that the Src-PTK associated with BCR phosphorylates the tyrosine residue(s) of SyK upon receptor stimulation, enhancing the activity of Syk.
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Protein tyrosine kinase syk is associated with and activated by the il-2 receptor: Possible link with the c-myc induction pathway
Yasuhiro Minami,Yoko Nakagawa,Atsuo Kawahara,Tadaski Miyazaki,Kiyonao Sada,Hirohei Yamamura,Tadatsugu Taniguchi +6 more
TL;DR: It is reported that Syk protein tyrosine kinase (PTK) is physically associated with IL-2R in peripheral blood lymphocytes and evidence is provided that in the hematopoietic cell line, BAF-B03, the activation of Syk PTK results in the induction of the c-myc gene, an event critical for the cell proliferation.
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Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering.
TL;DR: It is proposed that receptor clustering controls lyn‐mediated Fc epsilon RI tyrosine phosphorylation by shifting a balance between phosphorylated and dephosphorylation towards accumulation of tyrosines in response to receptor clustered.