Hirokazu Hirata

TL;DR: It is demonstrated that caspases are organized in a protease cascade, and that each activated caspase plays a distinct role(s) in the execution of Fas-induced cell death.

TL;DR: Observations suggest that a caspase cascade mediates apoptotic events and downregulates oxygen radical production in TNF-–treated neutrophils, and raise the possibility that suppression of caspases in neutrophil apoptosis with enhanced proinflammatory actions of TNP may underlie the pathogenesis of inflammatory diseases.

TL;DR: Findings provide evidence that caspase-8, a CrmA-sensitive protease, is responsible for initiating the stepwise activation of multiple caspases in Fas-stimulated cells.

TL;DR: The experience of a unique case of TAFRO syndrome in a 78-year-old woman whose symptoms responded differently to several therapies is presented, providing insight into the possible role of interleukin-2, in addition to interleucin-6, in TAF RO syndrome.

TL;DR: The efficacy and safety of Rd were consistent with data from larger studies, including the FIRST trial, thereby supporting the use of Rd continuous in Japanese patients with NDMM who are ineligible for stem cell transplantation.