A
Atsushi Takahashi
Researcher at Kyoto University
Publications - 30
Citations - 3835
Atsushi Takahashi is an academic researcher from Kyoto University. The author has contributed to research in topics: Apoptosis & Caspase. The author has an hindex of 22, co-authored 29 publications receiving 3786 citations. Previous affiliations of Atsushi Takahashi include Johns Hopkins University School of Medicine & Mayo Clinic.
Papers
More filters
Journal ArticleDOI
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
Atsushi Takahashi,Emad S. Alnemri,Yuri Lazebnik,Yuri Lazebnik,Teresa Fernandes-Alnemri,Gerald Litwack,Robert D. Moir,Robert D. Goldman,Guy G. Poirier,Scott H. Kaufmann,William C. Earnshaw,William C. Earnshaw +11 more
TL;DR: It is found that N-(acetyltyrosinylvalinyl-N epsilon-biotinyllysyl)aspartic acid can affinity label up to five active IRPs in S/M extracts.
Journal ArticleDOI
Modulation of cell death by Bcl-XL through caspase interaction.
Rollie J. Clem,Rollie J. Clem,Emily H. Cheng,Emily H. Cheng,Christopher L. Karp,David G. Kirsch,Kazuyoshi Ueno,Atsushi Takahashi,Atsushi Takahashi,Michael B. Kastan,Diane E. Griffin,William C. Earnshaw,William C. Earnshaw,Michael A. Veliuona,Michael A. Veliuona,J. Marie Hardwick +15 more
TL;DR: Findings indicate that the recognition/cleavage site of Bcl-XL may facilitate protection against cell death by acting at the level of caspase activation and that cleavage of BCl-XL during the execution phase of cell death converts B cl-XL from a protective to a lethal protein.
Journal ArticleDOI
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution
Yuri Lazebnik,Atsushi Takahashi,Robert D. Moir,Robert D. Goldman,Guy G. Poirier,Scott H. Kaufmann,Scott H. Kaufmann,William C. Earnshaw +7 more
TL;DR: These studies reveal that the lamin proteinase and the fragmentation nuclease function in independent parallel pathways during the final stages of apoptotic execution, and neither pathway alone is sufficient for completion of nuclear apoptosis.
Journal ArticleDOI
Caspases are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis
Hirokazu Hirata,Atsushi Takahashi,Susumu Kobayashi,Shin Yonehara,Hirofumi Sawai,Toshiro Okazaki,Kokichi Yamamoto,Masataka Sasada +7 more
TL;DR: It is demonstrated that caspases are organized in a protease cascade, and that each activated caspase plays a distinct role(s) in the execution of Fas-induced cell death.
Journal ArticleDOI
Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis
Luis M. Martins,Timothy Kottke,Peter W. Mesner,Guriqbal S. Basi,Sukanto Sinha,Normand Frigon,Eric Tatar,Jay S. Tung,Karin Bryant,Atsushi Takahashi,Phyllis A. Svingen,Benjamin J. Madden,Daniel J. McCormick,William C. Earnshaw,Scott H. Kaufmann +14 more
TL;DR: Etoposide-induced apoptosis in HL-60 cells is accompanied by the selective activation of multiple caspases in cytosol and nuclei, but the results suggest that other caspase precursors such as procaspase-2 are present but not activated during apoptosis.