H
Hiroshi Fujiwara
Researcher at National Institutes of Health
Publications - 24
Citations - 1276
Hiroshi Fujiwara is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 13, co-authored 23 publications receiving 1235 citations. Previous affiliations of Hiroshi Fujiwara include John Radcliffe Hospital & Roswell Park Cancer Institute.
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Journal ArticleDOI
Convenient Test for Screening Metallo-β-Lactamase-Producing Gram-Negative Bacteria by Using Thiol Compounds
Yoshichika Arakawa,Naohiro Shibata,Keigo Shibayama,Hiroshi Kurokawa,Tetsuya Yagi,Hiroshi Fujiwara,Masafumi Goto +6 more
TL;DR: A simple disk diffusion test was constructed for detection of IMP-1-type metallo-β-lactamase-producing gram-negative bacteria and the specificity and sensitivity were comparable to those of PCR analysis usingblaIMP-specific primers.
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Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation.
Katayoun Rezvani,Matthias Grube,Matthias Grube,Jason M. Brenchley,Jason M. Brenchley,Giuseppe Sconocchia,Giuseppe Sconocchia,Hiroshi Fujiwara,Hiroshi Fujiwara,David Price,David Price,Emma Gostick,Emma Gostick,Ko Yamada,Ko Yamada,J. Joseph Melenhorst,J. Joseph Melenhorst,Richard W. Childs,Richard W. Childs,Nancy F. Hensel,Nancy F. Hensel,Daniel C. Douek,Daniel C. Douek,A. John Barrett,A. John Barrett +24 more
TL;DR: The increased response in patients after SCT suggests a quantitative explanation for the greater effect of allogeneic stem cell transplantation (SCT) and derive from memory T cells and occur at low frequencies in healthy individuals and at higher frequencies in patients with CML.
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Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis.
Frank El Ouriaghli,Hiroshi Fujiwara,J. Joseph Melenhorst,Giuseppe Sconocchia,Nancy F. Hensel,A. John Barrett +5 more
TL;DR: Results support a role for neutrophil elastase in providing negative feedback to granulopoiesis by direct antagonism of G-CSF.
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In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
Hiroshi Fujiwara,J. Joseph Melenhorst,Frank El Ouriaghli,Sachiko Kajigaya,Matthias Grube,Giuseppe Sconocchia,Katayoun Rezvani,David Price,Nancy F. Hensel,Daniel C. Douek,A. John Barrett +10 more
TL;DR: T cells from a patient with chronic myelogenous leukemia and from a posttransplant CML patient, expanded against PGP, produced IFN-γ or were cytotoxic to the patient's CML cells, demonstrating specific antileukemic efficacy.
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The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions.
Giuseppe Sconocchia,Michelle Lau,Michelle Lau,Maurizio Provenzano,Maurizio Provenzano,Katayoun Rezvani,Wachanan Wongsena,Wachanan Wongsena,Hiroshi Fujiwara,Hiroshi Fujiwara,Nancy F. Hensel,Nancy F. Hensel,Jos Melenhorst,Jos Melenhorst,Jonming Li,Jonming Li,Soldano Ferrone,Soldano Ferrone,A. John Barrett +18 more
TL;DR: In vivo, CML cells may avoid NK-cell-mediated immune destruction by immune escape, shedding MICA into the plasma, thereby down-regulating NKG2D on CML CD56(+) cells, suggesting that killer inhibitory receptor (KIR) incompatibility was not essential for an antileukemic effect.