H
Hiroshi Fukuhara
Researcher at Kyorin University
Publications - 213
Citations - 4346
Hiroshi Fukuhara is an academic researcher from Kyorin University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 28, co-authored 195 publications receiving 3601 citations. Previous affiliations of Hiroshi Fukuhara include University of Tokyo.
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Oncolytic virus therapy: A new era of cancer treatment at dawn
TL;DR: It appears that it will not be long before oncolytic virus therapy becomes a standard therapeutic option for all cancer patients, following the success in immunotherapy using immune checkpoint inhibitors.
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TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.
Masami Kuramochi,Hiroshi Fukuhara,Takahiro Nobukuni,Takamasa Kanbe,Tomoko Maruyama,Hara P. Ghosh,Mathew T. Pletcher,Minoru Isomura,Masataka Onizuka,Tadaichi Kitamura,Takao Sekiya,Roger H. Reeves,Yoshinori Murakami +12 more
TL;DR: This region contains a single confirmed gene, TSLC1, whose expression is reduced or absent in A549 and several other NSCLC, hepatocellular carcinoma (HCC) and pancreatic cancer (PaC) cell lines, and is correlated with promoter methylation state in these cell lines.
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Physical and genetic organization of petite and grande yeast mitochondrial DNA: IV.† In vivo Transcription Products of Mitochondrial DNA and Localization of 23 S Ribosomal RNA in Petite Mutants of Saccharomyces cerevisiae☆
TL;DR: A series of isonuclear cytoplasmic petite (ϱ−) mutants presenting various patterns of large deletions and retentions in the C321R — E514R region was used to study the functional organization of mitochondrial DNA.
Journal Article
Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer.
Mika Yageta,Masami Kuramochi,Mari Masuda,Takeshi Fukami,Hiroshi Fukuhara,Tomoko Maruyama,Masabumi Shibuya,Yoshinori Murakami +7 more
TL;DR: Restoration of TSLC1 expression strongly suppressed the metastasis of a human non-small cell lung cancer cell line, A549, from the spleen to the liver in nude mice, suggesting that TS LC1 and DAL-1 play a critical role in the same pathway involved in the suppression of lung tumor formation and metastasis.
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The tumor suppressor protein TSLC1 is involved in cell-cell adhesion.
Mari Masuda,Mika Yageta,Hiroshi Fukuhara,Masami Kuramochi,Tomoko Maruyama,Akio Nomoto,Yoshinori Murakami +6 more
TL;DR: Results indicate that TSLC1 mediates intracellular adhesion through homophilic interactions in a Ca2+/Mg2+-independent manner.