H
Hiroshi Kohara
Researcher at Kyoto University
Publications - 19
Citations - 3580
Hiroshi Kohara is an academic researcher from Kyoto University. The author has contributed to research in topics: Stromal cell & Bone marrow. The author has an hindex of 11, co-authored 18 publications receiving 3218 citations. Previous affiliations of Hiroshi Kohara include Canon Inc..
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Journal ArticleDOI
Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches
TL;DR: It is shown that the induced deletion of CXCR4, a receptor for CXC chemokine ligand (CXCL) 12 in adult mice, resulted in severe reduction of HSC numbers and increased sensitivity to myelotoxic injury, although it did not impair expansion of the more mature progenitors.
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The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche
Yoshiki Omatsu,Tatsuki Sugiyama,Hiroshi Kohara,Gen Kondoh,Nobutaka Fujii,Kenji Kohno,Takashi Nagasawa +6 more
TL;DR: HSCs from CAR cell-depleted mice were reduced in number and cell size, were more quiescent, and had increased expression of early myeloid selector genes, similar to the phenotype of wild-type HSCs cultured without a niche.
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The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
Yoshitsugu Takabatake,Tatsuki Sugiyama,Hiroshi Kohara,Taiji Matsusaka,Taiji Matsusaka,Hidetake Kurihara,Pandelakis A. Koni,Yasuyuki Nagasawa,Takayuki Hamano,Isao Matsui,Noritaka Kawada,Enyu Imai,Takashi Nagasawa,Hiromi Rakugi,Yoshitaka Isaka +14 more
TL;DR: It is concluded that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney, suggesting new potential therapeutic targets for remodeling the injured kidney.
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Peripheral Nerve-Derived CXCL12 and VEGF-A Regulate the Patterning of Arterial Vessel Branching in Developing Limb Skin
Wenling Li,Hiroshi Kohara,Yutaka Uchida,Jennifer M. James,Kosha Soneji,Darran G. Cronshaw,Yong-Rui Zou,Takashi Nagasawa,Yoh-suke Mukouyama +8 more
TL;DR: These findings suggest a coordinated sequential action in which nerve Cxcl12 functions over a distance to recruit vessels to align with nerves, and subsequent arterial differentiation presumably requires a local action of nerve VEGF-A in the nerve-associated vessels.
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Synergistic effects of the dual release of stromal cell-derived factor-1 and bone morphogenetic protein-2 from hydrogels on bone regeneration.
TL;DR: It is concluded that the combined release of SDF-1 and BMP-2 enhanced the recruitment of osteogenic cells and angiogenesis, resulting in the synergistic effect on bone regeneration.