Y
Yoshiki Omatsu
Researcher at Osaka University
Publications - 29
Citations - 2971
Yoshiki Omatsu is an academic researcher from Osaka University. The author has contributed to research in topics: Bone marrow & Haematopoiesis. The author has an hindex of 17, co-authored 27 publications receiving 2685 citations. Previous affiliations of Yoshiki Omatsu include Kyoto University.
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Journal ArticleDOI
The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche
Yoshiki Omatsu,Tatsuki Sugiyama,Hiroshi Kohara,Gen Kondoh,Nobutaka Fujii,Kenji Kohno,Takashi Nagasawa +6 more
TL;DR: HSCs from CAR cell-depleted mice were reduced in number and cell size, were more quiescent, and had increased expression of early myeloid selector genes, similar to the phenotype of wild-type HSCs cultured without a niche.
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The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo
Tomonori Iyoda,Susumu Shimoyama,Kang Liu,Yoshiki Omatsu,Yuji Akiyama,Yasuhiro Maeda,Kazuhiko Takahara,Ralph M. Steinman,Kayo Inaba +8 more
TL;DR: It is shown directly that DCs in situ take up these types of cells after fluorescent labeling with carboxyfluorescein succinimidyl ester and injection into mice, indicating their selective ability to cross present cellular antigens to both CD4+ and CD8+ T cells.
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Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation
TL;DR: This study identifies Foxc1 as a specific transcriptional regulator essential for development and maintenance of the mesenchymal niches for haematopoietic stem and progenitor cells.
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Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-β1-dependent cells
Hiroaki Hemmi,Miya Yoshino,Hidetoshi Yamazaki,Makoto Naito,Tomonori Iyoda,Yoshiki Omatsu,Susumu Shimoyama,John J. Letterio,Toru Nakabayashi,Hisashi Tagaya,Toshiyuki Yamane,Minetaro Ogawa,Shin-Ichi Nishikawa,Kazuo Ryoke,Kayo Inaba,Shin-Ichi Hayashi,Takahiro Kunisada +16 more
TL;DR: Results indicate that antigens in the epidermis and dermis in the steady state are trafficked into regional LN only by TGF-beta1-dependent cells, which may be a dendritic cell lineage.
Journal ArticleDOI
Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins.
Kazuhiko Takahara,Yusuke Yashima,Yoshiki Omatsu,Hideo Yoshida,Yukino Kimura,Young-Sun Kang,Ralph M. Steinman,Chae Gyu Park,Kayo Inaba +8 more
TL;DR: These homologous C-type lectins have distinct recognition patters for microbes despite similarities in the carbohydrate recognition domains, and are competent to capture Gram-positive bacteria, Staphylococcus aureus.