H
Hiroshi Takata
Researcher at Walter Reed Army Institute of Research
Publications - 34
Citations - 1861
Hiroshi Takata is an academic researcher from Walter Reed Army Institute of Research. The author has contributed to research in topics: Cytotoxic T cell & Interleukin 21. The author has an hindex of 18, co-authored 28 publications receiving 1587 citations. Previous affiliations of Hiroshi Takata include Wistar Institute & Henry M. Jackson Foundation for the Advancement of Military Medicine.
Papers
More filters
Journal ArticleDOI
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.
Donn J Colby,Lydie Trautmann,Lydie Trautmann,Suteeraporn Pinyakorn,Suteeraporn Pinyakorn,Louise Leyre,Amélie Pagliuzza,Eugene Kroon,Morgane Rolland,Morgane Rolland,Hiroshi Takata,Hiroshi Takata,Supranee Buranapraditkun,Jintana Intasan,Nitiya Chomchey,Roshell Muir,Elias K. Haddad,Sodsai Tovanabutra,Sodsai Tovanabutra,Sasiwimol Ubolyam,Diane L. Bolton,Diane L. Bolton,Brandie A. Fullmer,Robert J. Gorelick,Lawrence Fox,Trevor A Crowell,Trevor A Crowell,Rapee Trichavaroj,Robert J. O'Connell,Nicolas Chomont,Jerome H. Kim,Jerome H. Kim,Nelson L. Michael,Merlin L. Robb,Merlin L. Robb,Nittaya Phanuphak,Jintanat Ananworanich +36 more
TL;DR: Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.
Journal ArticleDOI
Cutting edge: Phenotypic characterization and differentiation of human CD8+ T cells producing IL-17.
TL;DR: Analysis of the in vitro induction of Tc17 cells showed that these cells were induced from theCD27+CD28+CD45RA+ naive subset and that they expressed the CD27−CD28 + CD45RA− and CCR6+ phenotype, which indicates that Tc 17 cells have a unique phenotype and suggest that they differentiate from the same precursors that differentiate into IFN-γ-producing CD8+ T cells.
Journal ArticleDOI
Three memory subsets of human CD8+ T cells differently expressing three cytolytic effector molecules
TL;DR: The present study showed the existence of three memory subsets and the pathway for their differentiation, and suggested that the Per−GraA−GraB−, Per−/lowGraA+GraB+, and Perlow GraA+ GraB+ cells were central memory, early effector memory, and late effectorMemory T cells, respectively.
Journal ArticleDOI
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells
TL;DR: It is reported that mature naive CD8+ T cells lacking the transcription factor Foxp1 gained effector phenotype and function and proliferated directly in response to interleukin 7 (IL-7) in vitro, providing direct evidence that lymphocyte quiescence is achieved through actively maintained mechanisms that include transcriptional regulation.
Journal ArticleDOI
In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.
Cari F. Kessing,Christopher C. Nixon,Chuan Li,Perry Tsai,Hiroshi Takata,Hiroshi Takata,Guillaume Mousseau,Phong T. Ho,Jenna B. Honeycutt,Mohammad Fallahi,Lydie Trautmann,Lydie Trautmann,J. Victor Garcia,Susana T. Valente +13 more
TL;DR: It is shown that dCA mediates epigenetic silencing by increasing nucleosomal occupancy at Nucleosome-1, restricting RNAPII recruitment to the HIV-1 promoter, which demonstrates the potential of block-and-lock cure strategies.