Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.
Donn J Colby,Lydie Trautmann,Lydie Trautmann,Suteeraporn Pinyakorn,Suteeraporn Pinyakorn,Louise Leyre,Amélie Pagliuzza,Eugene Kroon,Morgane Rolland,Morgane Rolland,Hiroshi Takata,Hiroshi Takata,Supranee Buranapraditkun,Jintana Intasan,Nitiya Chomchey,Roshell Muir,Elias K. Haddad,Sodsai Tovanabutra,Sodsai Tovanabutra,Sasiwimol Ubolyam,Diane L. Bolton,Diane L. Bolton,Brandie A. Fullmer,Robert J. Gorelick,Lawrence Fox,Trevor A Crowell,Trevor A Crowell,Rapee Trichavaroj,Robert J. O'Connell,Nicolas Chomont,Jerome H. Kim,Jerome H. Kim,Nelson L. Michael,Merlin L. Robb,Merlin L. Robb,Nittaya Phanuphak,Jintanat Ananworanich +36 more
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Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.Abstract:
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.read more
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Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Pilar Mendoza,Henning Gruell,Lilian Nogueira,Joy A. Pai,Allison L. Butler,Katrina G. Millard,Clara Lehmann,Isabelle Suárez,Thiago Y. Oliveira,Julio C. C. Lorenzi,Yehuda Z. Cohen,Christoph Wyen,Christoph Wyen,Tim Kümmerle,Tim Kümmerle,Theodora K. Karagounis,Ching-Lan Lu,Lisa Handl,Cecilia Unson-O’Brien,Roshni Patel,Carola Ruping,Maike Schlotz,Maggi Witmer-Pack,Irina Shimeliovich,Gisela Kremer,Eleonore Thomas,Kelly E. Seaton,Jill Horowitz,Anthony P. West,Pamela J. Bjorkman,Georgia D. Tomaras,Roy M. Gulick,Nico Pfeifer,Gerd Fätkenheuer,Michael S. Seaman,Florian Klein,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +38 more
TL;DR: It is concluded that the combination of the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 can maintain long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.
Journal ArticleDOI
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection
Marion Pardons,Amy E. Baxter,Marta Massanella,Amélie Pagliuzza,Rémi Fromentin,Caroline Dufour,Louise Leyre,Jean-Pierre Routy,Daniel Kaufmann,Nicolas Chomont +9 more
TL;DR: A simple flow cytometry-based assay to quantify and characterize infected cells producing HIV proteins during untreated and treated HIV infection highlights a broad diversity in the phenotypes of HIV-infected cells in treated and untreated infection and suggests that strategies targeting multiple and phenotypically distinct cellular reservoirs will be needed to exert a significant impact on the size of the reservoir.
Journal ArticleDOI
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting
Boris Julg,Boris Julg,Lynda Dee,Jintanat Ananworanich,Dan H. Barouch,Dan H. Barouch,Katharine J. Bar,Marina Caskey,Donn J Colby,Liza Dawson,Krista L. Dong,Krista L. Dong,Karine Dubé,Joseph J. Eron,John Frater,Rajesh T. Gandhi,Romas Geleziunas,Philip J. R. Goulder,George J. Hanna,Richard Jefferys,Rowena Johnston,Daniel R. Kuritzkes,Jonathan Z. Li,Udom Likhitwonnawut,Jan van Lunzen,Javier Martinez-Picado,Javier Martinez-Picado,Veronica Miller,Luis J. Montaner,Douglas F. Nixon,David Palm,Giuseppe Pantaleo,Holly L. Peay,Deborah Persaud,Jessica Salzwedel,Karl Salzwedel,Timothy W. Schacker,Virginia Sheikh,Ole Schmeltz Søgaard,Serena Spudich,Kathryn E. Stephenson,Kathryn E. Stephenson,Jeremy Sugarman,Jeff Taylor,Pablo Tebas,Caroline T. Tiemessen,Randall Tressler,Carol D Weiss,Lu Zheng,Merlin L. Robb,Nelson L. Michael,John W. Mellors,Steven G. Deeks,Bruce D. Walker,Bruce D. Walker +54 more
TL;DR: This Review presents the major points of discussion and consensus views achieved with the goal of informing the conduct of ATIs to maximise the knowledge gained and minimise the risk to participants in clinical HIV research.
Journal ArticleDOI
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
TL;DR: The mechanisms thought to contribute to HIV persistence during treatment are described and findings from numerous recent studies describing the importance of cell proliferation in that process are highlighted.
Journal ArticleDOI
The Replication-Competent HIV-1 Latent Reservoir is Primarily Established Near the Time of Therapy Initiation
Melissa-Rose Abrahams,Sarah B. Joseph,Nigel Garrett,Lynn Tyers,Matthew Moeser,Nancie M. Archin,David Matten,Shuntai Zhou,Deelan Doolabh,Colin Anthony,Nilu Goonetilleke,Salim S. Abdool Karim,Salim S. Abdool Karim,David M. Margolis,Sergei L Kosakovsky Pond,Carolyn Williamson,Ronald Swanstrom +16 more
TL;DR: It is concluded that ART alters the host environment in a way that allows the formation or stabilization of most of the long-lived latent HIV-1 reservoir, which points to new strategies targeted at limiting the formation of the reservoir around the time of therapy initiation.
References
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Nicolas Chomont,Mohamed El-Far,Petronela Ancuta,Lydie Trautmann,Francesco A. Procopio,Bader Yassine-Diab,Geneviève Boucher,Mohamed Rachid Boulassel,Georges Ghattas,Jason M. Brenchley,Timothy W. Schacker,Brenna J. Hill,Daniel C. Douek,Jean-Pierre Routy,Elias K. Haddad,Elias K. Haddad,Rafick Pierre Sekaly +16 more
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TL;DR: The sequential emergence of assay reactivity allows the classification of primary HIV-1 infection into distinct laboratory stages, which may facilitate the diagnosis of recent infection and stratification of patients enrolled in clinical trials.
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