H
Hiroshi Ishiguro
Researcher at Nagoya University
Publications - 323
Citations - 8755
Hiroshi Ishiguro is an academic researcher from Nagoya University. The author has contributed to research in topics: Pancreatitis & Robot. The author has an hindex of 47, co-authored 319 publications receiving 8200 citations. Previous affiliations of Hiroshi Ishiguro include University of Manchester & Cornell University.
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Journal ArticleDOI
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
Masanori Asakura,Masafumi Kitakaze,Seiji Takashima,Yulin Liao,Fuminobu Ishikura,Tsuyoshi Yoshinaka,Hiroshi Ohmoto,Koichi Node,Kohichiro Yoshino,Hiroshi Ishiguro,Hiroshi Asanuma,Shoji Sanada,Yasushi Matsumura,Hiroshi Takeda,Shintaro Beppu,Michihiko Tada,Masatsugu Hori,Shigeki Higashiyama +17 more
TL;DR: It is suggested that inhibition of HB-EGF shedding could be a potent therapeutic strategy for cardiac hypertrophy and that dominant-negative expression of ADAM12 abrogated this signaling.
Journal ArticleDOI
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.
Takayoshi Shimohata,Toshihiro Nakajima,Mitsunori Yamada,Chiharu Uchida,Osamu Onodera,Satoshi Naruse,T. Kimura,Reiji Koide,Kenkichi Nozaki,Yasuteru Sano,Hiroshi Ishiguro,Kumi Sakoe,Takayuki Ooshima,Aki Sato,Takeshi Ikeuchi,Mutsuo Oyake,Toshiya Sato,Yasuyuki Aoyagi,Isao Hozumi,Toshiharu Nagatsu,Yoshihisa Takiyama,Masatoyo Nishizawa,Jun Goto,Ichiro Kanazawa,Irwin Davidson,Naoko Tanese,Hitoshi Takahashi,Shoji Tsuji +27 more
TL;DR: Results indicate that interference of transcription by the binding of TAFII130 with expanded polyQ stretches is involved in the pathogenetic mechanisms underlying neurodegeneration.
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A general method for introducing a series of mutations into cloned DNA using the polymerase chain reaction.
TL;DR: This paper describes the protocol for the site-directed mutagenesis and an example of the introduction of several mutations in the hen egg-white lysozyme-encoding gene.
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Mechanisms of bicarbonate secretion in the pancreatic duct
TL;DR: HCO3- efflux across the apical membrane is an electrogenic process that is facilitated by the depletion of intracellular Cl-, but it remains to be seen whether it is mediated predominantly by CFTR or by an electrogensic SLC26 anion exchanger.
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Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers
Masashi Kanai,Atsushi Imaizumi,Yoshihiko Otsuka,Hiroki Sasaki,Momo Hashiguchi,Kazu Tsujiko,Shigemi Matsumoto,Hiroshi Ishiguro,Tsutomu Chiba +8 more
TL;DR: THERACURMIN can safely increase plasma curcumin levels in a dose-dependent manner at least up to 210 mg without saturating the absorption system, and is the first nanoparticle formulation ofCurcumin that demonstrates improved bioavailability in human subjects.