H
Hiroto Eguchi
Researcher at Juntendo University
Publications - 23
Citations - 1261
Hiroto Eguchi is an academic researcher from Juntendo University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 20 publications receiving 1179 citations. Previous affiliations of Hiroto Eguchi include Nagasaki University.
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Journal ArticleDOI
TDP-43 mutation in familial amyotrophic lateral sclerosis
Akio Yokoseki,Atsushi Shiga,Chun-Feng Tan,Asako Tagawa,Hiroyuki Kaneko,Akihide Koyama,Hiroto Eguchi,Akira Tsujino,Takeshi Ikeuchi,Akiyoshi Kakita,Koichi Okamoto,Masatoyo Nishizawa,Hitoshi Takahashi,Osamu Onodera +13 more
TL;DR: In three affected individuals in two generations of one family, a single base‐pair change from A to G at position 1028 in TDP‐43 resulted in a Gln‐to‐Arg substitution at position 343, which provides a new insight into the molecular pathogenesis of ALS.
Journal ArticleDOI
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation.
Chun-Feng Tan,Hiroto Eguchi,Asako Tagawa,Osamu Onodera,Takuya Iwasaki,Akira Tsujino,Masatoyo Nishizawa,Akiyoshi Kakita,Hitoshi Takahashi +8 more
TL;DR: The findings indicate that the histological and molecular pathology of SALS can occur as a phenotype of FALS without SOD1 mutation.
Journal ArticleDOI
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
Sumihiro Kawajiri,Shinji Saiki,Shigeto Sato,Fumiaki Sato,Taku Hatano,Hiroto Eguchi,Nobutaka Hattori +6 more
TL;DR: This data indicates that direct interaction between LC3 and PINK1 and the anti bait coimmunoprecipitation mechanism is driven by a simple ‘spatially reprograming’ process.
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Japanese amyotrophic lateral sclerosis patients with GGGGCC hexanucleotide repeat expansion in C9ORF72.
Takuya Konno,Atsushi Shiga,Akira Tsujino,Akihiro Sugai,Taisuke Kato,Kazuaki Kanai,Akio Yokoseki,Hiroto Eguchi,Satoshi Kuwabara,Masatoyo Nishizawa,Hitoshi Takahashi,Osamu Onodera +11 more
TL;DR: Intriguingly, Japanese patients appear to carry the same risk haplotype identified in white populations, as C9ORF72 repeat expansions were present in a Japanese cohort of ALS patients, but they were rare.
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14-3-3 protein, total tau and phosphorylated tau in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease and neurodegenerative disease in Japan.
Katsuya Satoh,Susumu Shirabe,Hiroto Eguchi,Akira Tsujino,Katsumi Eguchi,Akira Satoh,Mitsuhiro Tsujihata,Masami Niwa,Shigeru Katamine,Saiko Kurihara,Hidenori Matsuo +10 more
TL;DR: The assay of t-tau protein may be useful as 1st screening and the ratio of p- tau protein/t-t Tau protein would be usefulAs 2nd screening to discriminate CJD from other neurodegenerative diseases in CSF.