Hiroyasu Kidoya

TL;DR: It is shown that pravastatin induced the VEGF-like angiogenic factor placental growth factor (PGF) and ameliorated the symptoms of preeclampsia, and the model identifies low-dose statins and PGF as candidates for preeClampsia treatment.

TL;DR: It is demonstrated that Trib1 is critical for adipose tissue maintenance and suppression of metabolic disorders by controlling the differentiation of tissue-resident M2-like macrophages.

TL;DR: Results indicated that the apelin/APJ system is involved in the regulation of blood vessel diameter during angiogenesis, and apelin enhanced endothelial cell proliferation in the presence of vascular endothelial growth factor and promoted cell‐to‐cell aggregation.

TL;DR: Although surface markers of this population are very similar to conventional ECs, and they reside in the capillary endothelium sub‐population, the gene expression profile is completely different, and the results suggest that this heterogeneity of stem‐like ECs will lead to the identification of new targets for vascular regeneration therapy.

TL;DR: It is shown that tissue-resident VESCs display self-renewal capacity and that vascular regeneration potential exists in peripheral blood vessels, supporting the existence of an endothelial hierarchy within blood vessels.