H
Hiroyuki Sugiyama
Researcher at National Institutes of Natural Sciences, Japan
Publications - 26
Citations - 2190
Hiroyuki Sugiyama is an academic researcher from National Institutes of Natural Sciences, Japan. The author has contributed to research in topics: Metabotropic glutamate receptor & Glutamate receptor. The author has an hindex of 19, co-authored 25 publications receiving 2145 citations. Previous affiliations of Hiroyuki Sugiyama include Kyushu University.
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Journal ArticleDOI
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit
Kenji Sakimura,Tatsuya Kutsuwada,Isao Ito,Toshiya Manabe,Chitoshi Takayama,Etsuko Kushiya,Takeshi Yagi,Shinichi Aizawa,Yoshiro Inoue,Hiroyuki Sugiyama,Masayoshi Mishina,Masayoshi Mishina +11 more
TL;DR: It is shown that targeted disruption of the mouse εl subunit gene resulted in significant reduction of the NMDA receptor channel current and long-term potentiation at the hippocampal CA1 synapses, which supports the notion that the NMda receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning.
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Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
TL;DR: Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices and the amplitudes of the potentiation were not changed by the formation of long‐term potentiation.
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Glutamate receptor subtypes may be classified into two major categories: a study on Xenopus oocytes injected with rat brain mRNA.
TL;DR: The metabotropic glutamate receptor belongs to a receptor category that is completely different from that of the other three receptor subtypes, not only functionally, but also pharmacologically.
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Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus.
TL;DR: The inhibitor, when applied in bathing solutions prior to and present during the tetanic stimulations, blocked the generation of long-term potentiation (LTP) in CA1 regions without affecting basal synaptic transmission itself, suggesting an important role of this kinase in the molecular mechanism of CA1 LTP.
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Differential effects of phospholipase inhibitors in long-term potentiation in the rat hippocampal mossy fiber synapses and Schaffer/commissural synapses
TL;DR: The results suggested that the mechanisms of LTP were quite different in the CA1 and CA3 subfields of rat hippocampus: in CA1, the involvement of an arachidonate metabolism was strongly suggested, whereas in CA3, anArachidonic acid cascade may not be necessary for LTP.