H
Hisako Ohba
Researcher at RIKEN Brain Science Institute
Publications - 41
Citations - 1533
Hisako Ohba is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Candidate gene. The author has an hindex of 19, co-authored 41 publications receiving 1344 citations.
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Journal ArticleDOI
Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia.
Kazuo Yamada,David J. Gerber,Yoshimi Iwayama,Tetsuo Ohnishi,Hisako Ohba,Tomoko Toyota,Jun Aruga,Yoshio Minabe,Susumu Tonegawa,Takeo Yoshikawa +9 more
TL;DR: The previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis is supported and EGR3 is identified as a compelling susceptibility gene.
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Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.
Kazuo Yamada,Tetsuo Ohnishi,Kenji Hashimoto,Hisako Ohba,Yoshimi Iwayama-Shigeno,Manabu Toyoshima,Akira Okuno,Hitomi Takao,Tomoko Toyota,Yoshio Minabe,Kazuhiko Nakamura,Eiji Shimizu,Masanari Itokawa,Norio Mori,Masaomi Iyo,Takeo Yoshikawa +15 more
TL;DR: The SRR/DAO are not likely to be major genetic determinants in the development of schizophrenia or control of serum D-serine levels, and genetic association analyses showed no significant association between SRR and DAO and schizophrenia.
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Genome-Wide Association Study of Schizophrenia in Japanese Population
Kazuo Yamada,Yoshimi Iwayama,Eiji Hattori,Kazuya Iwamoto,Tomoko Toyota,Tetsuo Ohnishi,Hisako Ohba,Motoko Maekawa,Tadafumi Kato,Takeo Yoshikawa +9 more
TL;DR: A three-stage analysis of three independent cohorts consisting of a total of 2,535 samples from Japanese and Chinese populations for searching schizophrenia susceptibility genes using a GWAS approach finds the current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology.
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A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia.
Masanari Itokawa,Kazuo Yamada,Kiyoshi Yoshitsugu,Tomoko Toyota,Toshiro Suga,Hisako Ohba,Akiko Watanabe,Eiji Hattori,Hiromitsu Shimizu,Tetsuo Kumakura,Mitsuru Ebihara,Joanne M.A. Meerabux,Michio Toru,Takeo Yoshikawa +13 more
TL;DR: Results illustrate a genotype-phenotype correlation in schizophrenia and suggest that the longer (GT)(n) stretch may act as a risk-conferring factor that worsens chronic outcome by reducing GRIN2A levels in the brain.
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A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.
Mika Aoki-Suzuki,Mika Aoki-Suzuki,Kazuo Yamada,Joanne M.A. Meerabux,Yoshimi Iwayama-Shigeno,Hisako Ohba,Kazuya Iwamoto,Hitomi Takao,Tomoko Toyota,Yumiko Suto,Noriaki Nakatani,Brian Dean,Sachiko Nishimura,Kenjiro Seki,Tadafumi Kato,Shigeyoshi Itohara,Toru Nishikawa,Takeo Yoshikawa +17 more
TL;DR: Specific haplotypes encompassing alternatively spliced exons of NTNG1 were associated with schizophrenia, and concordantly, messenger ribonucleic acid isoform expression was significantly different between schizophrenic and control brains.