Y
Yoshimi Iwayama
Researcher at RIKEN Brain Science Institute
Publications - 90
Citations - 3124
Yoshimi Iwayama is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Genetic association. The author has an hindex of 30, co-authored 85 publications receiving 2639 citations.
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Journal ArticleDOI
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.
Tetsushi Sadakata,Miwa Washida,Yoshimi Iwayama,Satoshi Shoji,Yumi Sato,Takeshi Ohkura,Ritsuko Katoh-Semba,Mizuho Nakajima,Yukiko Sekine,Mika Tanaka,Kazuhiko Nakamura,Yasuhide Iwata,Kenji J. Tsuchiya,Norio Mori,Sevilla D. Detera-Wadleigh,Hironobu Ichikawa,Shigeyoshi Itohara,Takeo Yoshikawa,Teiichi Furuichi +18 more
TL;DR: It is shown that Cadps2-knockout mice not only have impaired brain-derived neurotrophic factor release but also show autistic-like cellular and behavioral phenotypes, and the results suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autism susceptibility.
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Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype
Akiko Watanabe,Tomoko Toyota,Yuji Owada,Takeshi Hayashi,Yoshimi Iwayama,Miho Matsumata,Yuichi Ishitsuka,Akihiro Nakaya,Motoko Maekawa,Tetsuo Ohnishi,Ryoichi Arai,Katsuyasu Sakurai,Kazuo Yamada,Hisatake Kondo,Kenji Hashimoto,Noriko Osumi,Takeo Yoshikawa +16 more
TL;DR: The results suggest that FABP7 plays a novel and crucial role, linking the NMDA, neurodevelopmental, and glial theories of schizophrenia pathology and the PPI endophenotype, with larger or overt effects in males.
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Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia.
Kazuo Yamada,David J. Gerber,Yoshimi Iwayama,Tetsuo Ohnishi,Hisako Ohba,Tomoko Toyota,Jun Aruga,Yoshio Minabe,Susumu Tonegawa,Takeo Yoshikawa +9 more
TL;DR: The previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis is supported and EGR3 is identified as a compelling susceptibility gene.
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Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation
Noriaki Nakatani,Eiji Hattori,Tetsuo Ohnishi,Brian Dean,Yoshimi Iwayama,Izuru Matsumoto,Tadafumi Kato,Noriko Osumi,Teruhiko Higuchi,Shin-Ichi Niwa,Takeo Yoshikawa +10 more
TL;DR: In this paper, the authors examined the expression levels of more than 12,000 genes in Brodmann's Area (BA), 46 (dorsolateral prefrontal cortex) from bipolar I disorder and control samples using Affymetrix GeneChips.
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Brain region-specific altered expression and association of mitochondria-related genes in autism
Ayyappan Anitha,Kazuhiko Nakamura,Ismail Thanseem,Kazuo Yamada,Yoshimi Iwayama,Tomoko Toyota,Hideo Matsuzaki,Taishi Miyachi,Satoru Yamada,Masatsugu Tsujii,Masatsugu Tsujii,Kenji J. Tsuchiya,Kaori Matsumoto,Yasuhide Iwata,Katsuaki Suzuki,Hironobu Ichikawa,Toshiro Sugiyama,Takeo Yoshikawa,Norio Mori +18 more
TL;DR: If MtD is detected in early stages, treatment strategies aimed at reducing its impact may be adopted and some new genes associated with MtD in autism are brought to light.