T
Tomoko Toyota
Researcher at RIKEN Brain Science Institute
Publications - 91
Citations - 4041
Tomoko Toyota is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Genetic association. The author has an hindex of 35, co-authored 87 publications receiving 3450 citations.
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Journal ArticleDOI
Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype
Akiko Watanabe,Tomoko Toyota,Yuji Owada,Takeshi Hayashi,Yoshimi Iwayama,Miho Matsumata,Yuichi Ishitsuka,Akihiro Nakaya,Motoko Maekawa,Tetsuo Ohnishi,Ryoichi Arai,Katsuyasu Sakurai,Kazuo Yamada,Hisatake Kondo,Kenji Hashimoto,Noriko Osumi,Takeo Yoshikawa +16 more
TL;DR: The results suggest that FABP7 plays a novel and crucial role, linking the NMDA, neurodevelopmental, and glial theories of schizophrenia pathology and the PPI endophenotype, with larger or overt effects in males.
Journal ArticleDOI
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights
Itaru Kushima,Branko Aleksic,Masahiro Nakatochi,Teppei Shimamura,Takashi Okada,Yota Uno,Yota Uno,Mako Morikawa,Kanako Ishizuka,Tomoko Shiino,Hiroki Kimura,Yuko Arioka,Akira Yoshimi,Yuto Takasaki,Yanjie Yu,Yukako Nakamura,Maeri Yamamoto,Tetsuya Iidaka,Shuji Iritani,Toshiya Inada,Nanayo Ogawa,Emiko Shishido,Youta Torii,Naoko Kawano,Yutaka Omura,Toru Yoshikawa,Tokio Uchiyama,Toshimichi Yamamoto,Masashi Ikeda,Ryota Hashimoto,Hidenaga Yamamori,Yuka Yasuda,Toshiyuki Someya,Yuichiro Watanabe,Jun Egawa,Ayako Nunokawa,Masanari Itokawa,Makoto Arai,Mitsuhiro Miyashita,Akiko Kobori,Michio Suzuki,Tsutomu Takahashi,Masahide Usami,Masaki Kodaira,Kyota Watanabe,Tsukasa Sasaki,Hitoshi Kuwabara,Mamoru Tochigi,Fumichika Nishimura,Hidenori Yamasue,Yosuke Eriguchi,Seico Benner,Masaki Kojima,Walid Yassin,Toshio Munesue,Shigeru Yokoyama,Ryo Kimura,Yasuko Funabiki,Hirotaka Kosaka,Makoto Ishitobi,Tetsuro Ohmori,Shusuke Numata,Takeo Yoshikawa,Tomoko Toyota,Kazuhiro Yamakawa,Toshimitsu Suzuki,Yushi Inoue,Kentaro Nakaoka,Yu-ichi Goto,Masumi Inagaki,Naoki Hashimoto,Ichiro Kusumi,Shuraku Son,Toshiya Murai,Tempei Ikegame,Naohiro Okada,Kiyoto Kasai,Shohko Kunimoto,Daisuke Mori,Nakao Iwata,Norio Ozaki +80 more
TL;DR: An etiological overlap of ASD and SCZ is suggested and multiple disease-relevant genes in eight well-known ASD/SCZ-associated CNV loci are identified, which provide biological insights into these disorders.
Journal ArticleDOI
Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia.
Kazuo Yamada,David J. Gerber,Yoshimi Iwayama,Tetsuo Ohnishi,Hisako Ohba,Tomoko Toyota,Jun Aruga,Yoshio Minabe,Susumu Tonegawa,Takeo Yoshikawa +9 more
TL;DR: The previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis is supported and EGR3 is identified as a compelling susceptibility gene.
Journal ArticleDOI
Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia
Makoto Arai,Hiroko Yuzawa,Izumi Nohara,Tetsuo Ohnishi,Nanako Obata,Yoshimi Iwayama,Seiichi Haga,Tomoko Toyota,Hiroshi Ujike,Mayumi Arai,Tomoe Ichikawa,Atsushi Nishida,Yoko Tanaka,Aizo Furukawa,Yuuzou Aikawa,Osamu Kuroda,Kazuhiro Niizato,Ryosuke Izawa,Kazuhiko Nakamura,Norio Mori,Daisuke Matsuzawa,Kenji Hashimoto,Masaomi Iyo,Ichiro Sora,Masaaki Matsushita,Yuji Okazaki,Takeo Yoshikawa,Toshio Miyata,Masanari Itokawa +28 more
TL;DR: Elevated plasma pentosidine and concomitant low vitamin B(6) levels could be the most cogent and easily measurable biomarkers in schizophrenia and should be helpful for classifying heterogeneous types of schizophrenia on the basis of their biological causes.
Journal ArticleDOI
Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.
Kazuo Yamada,Tetsuo Ohnishi,Kenji Hashimoto,Hisako Ohba,Yoshimi Iwayama-Shigeno,Manabu Toyoshima,Akira Okuno,Hitomi Takao,Tomoko Toyota,Yoshio Minabe,Kazuhiko Nakamura,Eiji Shimizu,Masanari Itokawa,Norio Mori,Masaomi Iyo,Takeo Yoshikawa +15 more
TL;DR: The SRR/DAO are not likely to be major genetic determinants in the development of schizophrenia or control of serum D-serine levels, and genetic association analyses showed no significant association between SRR and DAO and schizophrenia.