Hisashi Kanemaru

TL;DR: Serum levels of miR-221 were significantly increased in MM patients and may be useful not only for the diagnosis of MM, but also for the differentiating MM in situ from stage I-IV MM, and for evaluating tumor progression and monitoring patients during the follow-up period.

TL;DR: Findings clearly suggest a role for Dectin-1-mediated sensocrine pathways in the resolution of fungal osteoinflammation.

TL;DR: It is shown that the C. albicans-specific signaling pathway led to severe mechanical allodynia and the first report to indicate that Dectin-1 and VNUT mediated innate sensory mechanisms that detect fungal infection.

TL;DR: It is found that basic leucine zipper transcription factor ATF-like 2 (Batf2) has an antitumor effect through the up-regulation of IL-12 p40 in tumor-associated macrophages, which eventually induces CD8+ T-cell activation and accumulation within the tumor.

TL;DR: Investigation of the FOXM1 expression in human melanoma samples and cell lines found it to be a new therapeutic target for melanoma, and downregulation of FOXM 1 by siRNA significantly inhibited the proliferation of melanoma cells, and blockade of the MAPK and PI3K/AKT pathways decreased the FoxM 1 expression in melanoma cell lines.