Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis
Kenta Maruyama,Yasunori Takayama,Takeshi Kondo,Ken ichi Ishibashi,Bikash R. Sahoo,Hisashi Kanemaru,Yutaro Kumagai,Mikaël M. Martino,Hiroki Tanaka,Naohito Ohno,Yoichiro Iwakura,Naoki Takemura,Makoto Tominaga,Makoto Tominaga,Shizuo Akira +14 more
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Findings clearly suggest a role for Dectin-1-mediated sensocrine pathways in the resolution of fungal osteoinflammation.About:
This article is published in Cell Reports.The article was published on 2017-06-27 and is currently open access. It has received 67 citations till now. The article focuses on the topics: Calcitonin gene-related peptide & TRPV1.read more
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Osteoimmunology: evolving concepts in bone–immune interactions in health and disease
TL;DR: It is well known that immune cells can have profound effects on bone cells, but this interaction is not unidirectional, so Tsukasaki and Takayanagi explore the reciprocal dialogue between bone cells and immune cells during health and disease.
Journal ArticleDOI
Pain and immunity: implications for host defence
TL;DR: The role of nociceptor interactions with the immune system in pain and infection is discussed and how understanding these pathways could produce new approaches to treat infectious diseases and chronic pain is discussed.
Journal ArticleDOI
The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis.
Teruki Dainichi,Akihiko Kitoh,Atsushi Otsuka,Saeko Nakajima,Takashi Nomura,Daniel H. Kaplan,Kenji Kabashima,Kenji Kabashima +7 more
TL;DR: The pathogenesis of atopic dermatitis and psoriasis is discussed in terms of the epithelial immune microenvironment—the microbiota, keratinocytes and sensory nerves—and the resulting inflammatory loops.
Journal ArticleDOI
Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity
Jonathan A. Cohen,Tara N. Edwards,Andrew Liu,Toshiro Hirai,Marsha Ritter Jones,Jianing Wu,Yao Li,Shiqun Zhang,Jonhan Ho,Brian M. Davis,Kathryn M. Albers,Daniel H. Kaplan +11 more
TL;DR: The sufficiency of TRPV1+ neuron activation for host defense is shown and the existence of functional anticipatory innate immunity at sites adjacent to infection that depends on antidromic neuron activation is demonstrated.
Journal ArticleDOI
Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense
Nicole Y. Lai,Melissa A. Musser,Melissa A. Musser,Felipe A. Pinho-Ribeiro,Pankaj Baral,Amanda Jacobson,Pingchuan Ma,David E. Potts,Zuojia Chen,Zuojia Chen,Donggi Paik,Salima Soualhi,Yiqing Yan,Aditya Misra,Kaitlin Goldstein,Valentina N. Lagomarsino,Anja Nordstrom,Kisha N. Sivanathan,Antonia Wallrapp,Vijay K. Kuchroo,Roni Nowarski,Michael N. Starnbach,Hailian Shi,Hailian Shi,Neeraj K. Surana,Dingding An,Chuan Wu,Chuan Wu,Jun R. Huh,Meenakshi Rao,Isaac M. Chiu +30 more
TL;DR: It is found that nociceptor neurons critically mediate host defense against the bacterial pathogen Salmonella enterica serovar Typhimurium (STm), and a major role is revealed in sensing and defending against enteric pathogens.
References
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Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.
Katsuaki Hoshino,Osamu Takeuchi,Taro Kawai,Hideki Sanjo,Tomohiko Ogawa,Yoshifumi Takeda,Kiyoshi Takeda,Shizuo Akira +7 more
TL;DR: It is demonstrated that TLR4 is the gene product that regulates LPS response, and a single point mutation of the amino acid that is highly conserved among the IL-1/Toll receptor family is found.
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Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
Michael J. Caterina,A. Leffler,Annika B. Malmberg,William J. Martin,Jodie A. Trafton,K. R. Petersen-Zeitz,Martin Koltzenburg,Allan I. Basbaum,David Julius +8 more
TL;DR: Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.
Journal ArticleDOI
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
Diana M. Bautista,Sven-Eric Jordt,Tetsuro Nikai,Pamela R. Tsuruda,Andrew J. Read,Jeannie Poblete,Ebenezer N. Yamoah,Allan I. Basbaum,David Julius +8 more
TL;DR: Using TRPA1-deficient mice, it is shown that this channel is the sole target through which mustard oil and garlic activate primary afferent nociceptors to produce inflammatory pain.
Journal ArticleDOI
TRP Channels and Pain
TL;DR: Analysis of TRP channel function and expression has validated the existence of nociceptors as a specialized group of somatosensory neurons devoted to the detection of noxious stimuli and is providing insight into the coding logic of nnociception and how specification of nOCiceptor subtypes underlies behavioral discrimination ofNoxious thermal, chemical, and mechanical stimuli.
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Candida albicans morphogenesis and host defence: discriminating invasion from colonization
TL;DR: The properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans are described.
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