H
Hitoshi Kikutani
Researcher at Osaka University
Publications - 161
Citations - 16521
Hitoshi Kikutani is an academic researcher from Osaka University. The author has contributed to research in topics: Semaphorin & Receptor. The author has an hindex of 62, co-authored 157 publications receiving 15871 citations.
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Journal ArticleDOI
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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Molecular cloning and structure of a pre-B-cell growth-stimulating factor
TL;DR: A stromal cell line, PA6, was found to produce a soluble mediator, which was distinct from interleukin 7 (IL-7) and stem cell factor and supported the proliferation of a stromAL cell-dependent pre-B-cell clone, DW34.
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From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
Anne-Sophie Korganow,Hong Ji,Sara Mangialaio,Veronique Duchatelle,Roberta Pelanda,Thierry Martin,Claude Degott,Hitoshi Kikutani,Klaus Rajewsky,Jean-Louis Pasquali,Christophe Benoist,Diane Mathis +11 more
TL;DR: The role of B cells as the secretion of arthritogenic immunoglobulins is identified in rheumatoid arthritis and it is suggested that a similar scenario may unfold in some other arthritis models and in human patients, beginning with pervasive T cell autoreactivity and ending in immunoglobeulin-provoked joint destruction.
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Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses
Junji Uchida,Teruhito Yasui,Yuko Takaoka-Shichijo,Masaaki Muraoka,Wanla Kulwichit,Nancy Raab-Traub,Hitoshi Kikutani +6 more
TL;DR: Investigation of the effect of the Epstein-Barr virus latent membrane protein 1 on the activation and differentiation of normal B cells revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation.
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Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23.
Faming Wang,C D Gregory,Meredith L. Rowe,Alan B. Rickinson,David Q.-H. Wang,Mark Birkenbach,Hitoshi Kikutani,Tadamitsu Kishimoto,Elliott Kieff +8 more
TL;DR: The results indicate that EBNA-2 is a specific direct or indirect trans-activator of CD23, which could be important in EBV induction of B-lymphocyte transformation.