Hitoshi Sohma

TL;DR: The structural elements of the lung collectins involved in CD14 recognition and the consequences for CD14/LPS interaction are examined to conclude that 1) lung collectin bind CD14, 2) the SP-A neck domain and SP-D lectin domain participate inCD14 binding, 3) SP- a recognizes a peptide component and SP -D recognizes a carbohydrate moiety of CD14; and 4) lung Collectins alter LPS/CD14 interactions.

TL;DR: The results demonstrate the different actions of SP-A upon distinct serotypes of LPS and indicate that the direct interaction ofSP-A with CD14 constitutes a likely mechanism by which SP- A modulates LPS-elicited cellular responses.

TL;DR: CCL8 is a promising specific serum marker for the early and accurate diagnosis of GVHD, a member of a large chemokine family associated with graft-versus-host disease.

TL;DR: The functional region in the carbohydrate recognition domain of rat SP-A and SP-D that is involved in binding lipids and interacting with alveolar type II cells by using chimeric proteins is investigated and it is concluded that theSP-A region of Glu195–Phe228 is required for lipid and type II cell interactions.

TL;DR: The role of copines in regulating signalling from the TNF-alpha (tumour necrosis factor-alpha) receptor was probed by the expression of a copine dominant-negative construct in HEK293 cells, and a hypothesis is presented for possible roles of copine in regulating other signalling pathways in animals, plants and protozoa.